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The Vitamin D Receptor as a Prognostic Marker in Breast Cancer-A Cohort Study

Huss, Linnea LU ; Gulz-Haake, Igis LU ; Nilsson, Emma LU ; Tryggvadottir, Helga LU ; Nilsson, Linn LU ; Nodin, Björn LU ; Jirström, Karin LU orcid ; Isaksson, Karolin LU and Jernström, Helena LU (2024) In Nutrients 16(7). p.1-15
Abstract

Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The VDR protein levels were analyzed using immunohistochemistry in tumor samples from 878 breast cancer patients from Lund, Sweden, included in the Breast Cancer and Blood Study (BCBlood) from October 2002 to June 2012. The follow-up for breast cancer events and overall survival was recorded until 30 June 2019. Univariable and multivariable survival analyses were conducted, both with complete case data and with missing data imputed using multiple imputation by... (More)

Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The VDR protein levels were analyzed using immunohistochemistry in tumor samples from 878 breast cancer patients from Lund, Sweden, included in the Breast Cancer and Blood Study (BCBlood) from October 2002 to June 2012. The follow-up for breast cancer events and overall survival was recorded until 30 June 2019. Univariable and multivariable survival analyses were conducted, both with complete case data and with missing data imputed using multiple imputation by chained equations (MICE). Tumor-specific positive nuclear membrane VDR(num) staining was associated with favorable tumor characteristics and a longer breast cancer free interval (BCFI; HR: 0.64; 95% CI: 0.44-0.95) and overall survival (OS; HR: 0.52; 95% CI: 0.34-0.78). Further analyses indicated that VDRnum status also was predictive of overall survival when investigated in relation to ER status. There were significant interactions between VDR and invasive tumor size (Pinteraction = 0.047), as well as mode of detection (Pinteraction = 0.049). VDRnum was associated with a longer BCFI in patients with larger tumors (HR: 0.36; 95% CI: 0.14-0.93) or clinically detected tumors (HR: 0.28; 95% CI: 0.09-0.83), while no association was found for smaller tumors and screening-detected tumors. Further studies are suggested to confirm our results and to evaluate whether VDR should and could be used as a prognostic and targetable marker in breast cancer diagnostics.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Female, Breast Neoplasms/diagnosis, Cohort Studies, Receptors, Calcitriol, Prognosis, Breast
in
Nutrients
volume
16
issue
7
article number
931
pages
1 - 15
publisher
MDPI AG
external identifiers
  • pmid:38612962
ISSN
2072-6643
DOI
10.3390/nu16070931
language
English
LU publication?
yes
id
310acc99-b588-4aff-885d-4d8504d396fc
date added to LUP
2024-04-16 20:53:09
date last changed
2024-04-17 08:54:50
@article{310acc99-b588-4aff-885d-4d8504d396fc,
  abstract     = {{<p>Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The VDR protein levels were analyzed using immunohistochemistry in tumor samples from 878 breast cancer patients from Lund, Sweden, included in the Breast Cancer and Blood Study (BCBlood) from October 2002 to June 2012. The follow-up for breast cancer events and overall survival was recorded until 30 June 2019. Univariable and multivariable survival analyses were conducted, both with complete case data and with missing data imputed using multiple imputation by chained equations (MICE). Tumor-specific positive nuclear membrane VDR(num) staining was associated with favorable tumor characteristics and a longer breast cancer free interval (BCFI; HR: 0.64; 95% CI: 0.44-0.95) and overall survival (OS; HR: 0.52; 95% CI: 0.34-0.78). Further analyses indicated that VDRnum status also was predictive of overall survival when investigated in relation to ER status. There were significant interactions between VDR and invasive tumor size (Pinteraction = 0.047), as well as mode of detection (Pinteraction = 0.049). VDRnum was associated with a longer BCFI in patients with larger tumors (HR: 0.36; 95% CI: 0.14-0.93) or clinically detected tumors (HR: 0.28; 95% CI: 0.09-0.83), while no association was found for smaller tumors and screening-detected tumors. Further studies are suggested to confirm our results and to evaluate whether VDR should and could be used as a prognostic and targetable marker in breast cancer diagnostics.</p>}},
  author       = {{Huss, Linnea and Gulz-Haake, Igis and Nilsson, Emma and Tryggvadottir, Helga and Nilsson, Linn and Nodin, Björn and Jirström, Karin and Isaksson, Karolin and Jernström, Helena}},
  issn         = {{2072-6643}},
  keywords     = {{Humans; Female; Breast Neoplasms/diagnosis; Cohort Studies; Receptors, Calcitriol; Prognosis; Breast}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{7}},
  pages        = {{1--15}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{The Vitamin D Receptor as a Prognostic Marker in Breast Cancer-A Cohort Study}},
  url          = {{http://dx.doi.org/10.3390/nu16070931}},
  doi          = {{10.3390/nu16070931}},
  volume       = {{16}},
  year         = {{2024}},
}