Endothelial damage after treatment with low-molecular weight heparins - a morphological study
(2003) In Scandinavian Cardiovascular Journal 37(1). p.30-33- Abstract
- Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study investigates the influence of LMWH currently in clinical use on arterial endothelium in vivo. Design-Eighty rabbits in four groups were treated with dalteparin, enoxaparin, tinzaparin and saline, respectively. Arterial endothelium was examined after 3, 14, 30 and 60 days with scanning electron microscopy. Results-All three groups treated with LMWH... (More)
- Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study investigates the influence of LMWH currently in clinical use on arterial endothelium in vivo. Design-Eighty rabbits in four groups were treated with dalteparin, enoxaparin, tinzaparin and saline, respectively. Arterial endothelium was examined after 3, 14, 30 and 60 days with scanning electron microscopy. Results-All three groups treated with LMWH showed moderate damage to the endothelium, with contracted vessel wall and endothelial cells, cell membrane damage, denudation of subendothelium and adhering platelets. Contrarily, the control group exhibited a normal endothelium. Conclusion-Morphologic examination of arterial endothelium shows that all investigated LMWH exert a moderate toxic effect on endothelial cells. The clinical impact of these observations, e. g. concerning effect of long-term LMWH treatment, needs to be further elucidated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/312395
- author
- Kinhult, Sara LU ; Eskilsson, Jan LU ; Albertsson, Maria LU and Cwikiel, Magdalena LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- scanning electron microscopy, endothelium, low molecular weight heparin
- in
- Scandinavian Cardiovascular Journal
- volume
- 37
- issue
- 1
- pages
- 30 - 33
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000182593000005
- pmid:12745800
- scopus:0037649979
- ISSN
- 1651-2006
- DOI
- 10.1080/14017430310007009
- language
- English
- LU publication?
- yes
- id
- 133e8466-c0e8-40c8-ba09-41a1814ba0b3 (old id 312395)
- date added to LUP
- 2016-04-01 16:35:42
- date last changed
- 2022-01-28 20:45:00
@article{133e8466-c0e8-40c8-ba09-41a1814ba0b3,
abstract = {{Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study investigates the influence of LMWH currently in clinical use on arterial endothelium in vivo. Design-Eighty rabbits in four groups were treated with dalteparin, enoxaparin, tinzaparin and saline, respectively. Arterial endothelium was examined after 3, 14, 30 and 60 days with scanning electron microscopy. Results-All three groups treated with LMWH showed moderate damage to the endothelium, with contracted vessel wall and endothelial cells, cell membrane damage, denudation of subendothelium and adhering platelets. Contrarily, the control group exhibited a normal endothelium. Conclusion-Morphologic examination of arterial endothelium shows that all investigated LMWH exert a moderate toxic effect on endothelial cells. The clinical impact of these observations, e. g. concerning effect of long-term LMWH treatment, needs to be further elucidated.}},
author = {{Kinhult, Sara and Eskilsson, Jan and Albertsson, Maria and Cwikiel, Magdalena}},
issn = {{1651-2006}},
keywords = {{scanning electron microscopy; endothelium; low molecular weight heparin}},
language = {{eng}},
number = {{1}},
pages = {{30--33}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Cardiovascular Journal}},
title = {{Endothelial damage after treatment with low-molecular weight heparins - a morphological study}},
url = {{http://dx.doi.org/10.1080/14017430310007009}},
doi = {{10.1080/14017430310007009}},
volume = {{37}},
year = {{2003}},
}