DNA with double-chained amphiphilic counterions and its interaction with lecithin.
(2012) In Langmuir 28(38). p.13698-13704- Abstract
- Complex salts of double-stranded DNA with amphiphilic counterions offer novel opportunities for studies of DNA-lipid interactions. Here the effect of the hydrophobicity of the amphiphilic counterion is in focus. For this purpose, double stranded DNA with didodecyldimethylammonium ions as counterions, DDADNA, is prepared and investigated with respect to microstructure. In particular, in order to monitor the interactions with phospholipids, the phase diagram of the DDADNA/lecithin/water system is determined and compared with the previously determined phase diagram with single alkyl chain counterions, dodecyltrimethylammonium, DTA. In both systems, there is a formation of lamellar and reverse hexagonal phases, where hydrated DNA is sandwiched... (More)
- Complex salts of double-stranded DNA with amphiphilic counterions offer novel opportunities for studies of DNA-lipid interactions. Here the effect of the hydrophobicity of the amphiphilic counterion is in focus. For this purpose, double stranded DNA with didodecyldimethylammonium ions as counterions, DDADNA, is prepared and investigated with respect to microstructure. In particular, in order to monitor the interactions with phospholipids, the phase diagram of the DDADNA/lecithin/water system is determined and compared with the previously determined phase diagram with single alkyl chain counterions, dodecyltrimethylammonium, DTA. In both systems, there is a formation of lamellar and reverse hexagonal phases, where hydrated DNA is sandwiched between bilayers or forms the core of reverse cylindrical micelles, respectively. However, whereas the lecithin lamellar phase can incorporate large amounts of DDADNA, there is in the case of the single chain surfactant, DTADNA, a transition to a bicontinuous cubic phase at higher DTADNA concentrations. The general appearance of the phase diagrams, and in particular the role of counterion hydrophobicity, can be rationalized in a simple geometric model. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3124401
- author
- Krivtsov, Alexey LU ; Bilalov, Azat LU ; Olsson, Ulf LU and Lindman, Björn LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 28
- issue
- 38
- pages
- 13698 - 13704
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000309040800019
- pmid:22943435
- scopus:84866647348
- pmid:22943435
- ISSN
- 0743-7463
- DOI
- 10.1021/la302720d
- language
- English
- LU publication?
- yes
- id
- 98e15160-e436-4d85-addd-1873de8dc128 (old id 3124401)
- date added to LUP
- 2016-04-01 11:13:18
- date last changed
- 2022-01-26 06:18:43
@article{98e15160-e436-4d85-addd-1873de8dc128, abstract = {{Complex salts of double-stranded DNA with amphiphilic counterions offer novel opportunities for studies of DNA-lipid interactions. Here the effect of the hydrophobicity of the amphiphilic counterion is in focus. For this purpose, double stranded DNA with didodecyldimethylammonium ions as counterions, DDADNA, is prepared and investigated with respect to microstructure. In particular, in order to monitor the interactions with phospholipids, the phase diagram of the DDADNA/lecithin/water system is determined and compared with the previously determined phase diagram with single alkyl chain counterions, dodecyltrimethylammonium, DTA. In both systems, there is a formation of lamellar and reverse hexagonal phases, where hydrated DNA is sandwiched between bilayers or forms the core of reverse cylindrical micelles, respectively. However, whereas the lecithin lamellar phase can incorporate large amounts of DDADNA, there is in the case of the single chain surfactant, DTADNA, a transition to a bicontinuous cubic phase at higher DTADNA concentrations. The general appearance of the phase diagrams, and in particular the role of counterion hydrophobicity, can be rationalized in a simple geometric model.}}, author = {{Krivtsov, Alexey and Bilalov, Azat and Olsson, Ulf and Lindman, Björn}}, issn = {{0743-7463}}, language = {{eng}}, number = {{38}}, pages = {{13698--13704}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Langmuir}}, title = {{DNA with double-chained amphiphilic counterions and its interaction with lecithin.}}, url = {{http://dx.doi.org/10.1021/la302720d}}, doi = {{10.1021/la302720d}}, volume = {{28}}, year = {{2012}}, }