Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease
(2012) In Particle and Fibre Toxicology 9.- Abstract
- Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods: Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous... (More)
- Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods: Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous breathing. Results: The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (< 100 nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function. Conclusions: The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20-30 nm, suggest that altered particle deposition could be used as an indicator respiratory disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3139769
- author
- Löndahl, Jakob LU ; Swietlicki, Erik LU ; Rissler, Jenny LU ; Bengtsson, Agneta LU ; Boman, Christoffer ; Blomberg, Anders and Sandstrom, Thomas
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lung deposition, Toxicity, Health effects, Air pollution, Agglomerate, Nanoparticles, Aerosol, COPD, Diesel exhaust
- in
- Particle and Fibre Toxicology
- volume
- 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000308668200001
- scopus:84864229214
- pmid:22839109
- ISSN
- 1743-8977
- DOI
- 10.1186/1743-8977-9-30
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007), Ergonomics and Aerosol Technology (011025002)
- id
- 7f4c4ecc-a946-4801-b560-9c8dd0a21567 (old id 3139769)
- date added to LUP
- 2016-04-01 12:58:01
- date last changed
- 2023-11-12 10:25:51
@article{7f4c4ecc-a946-4801-b560-9c8dd0a21567, abstract = {{Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods: Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous breathing. Results: The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (< 100 nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function. Conclusions: The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20-30 nm, suggest that altered particle deposition could be used as an indicator respiratory disease.}}, author = {{Löndahl, Jakob and Swietlicki, Erik and Rissler, Jenny and Bengtsson, Agneta and Boman, Christoffer and Blomberg, Anders and Sandstrom, Thomas}}, issn = {{1743-8977}}, keywords = {{Lung deposition; Toxicity; Health effects; Air pollution; Agglomerate; Nanoparticles; Aerosol; COPD; Diesel exhaust}}, language = {{eng}}, publisher = {{BioMed Central (BMC)}}, series = {{Particle and Fibre Toxicology}}, title = {{Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease}}, url = {{https://lup.lub.lu.se/search/files/3076761/3167615.pdf}}, doi = {{10.1186/1743-8977-9-30}}, volume = {{9}}, year = {{2012}}, }