Beneficial Effects of Hormone Replacement Therapy on Periodontitis are Vitamin D Associated.
(2013) In Journal of Periodontology 84(8). p.1048-1057- Abstract
- Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes cross-sectional data from the continuous NHANES 2001-2004. The cross-sections include n=1,230 women aged 40-85 who received a periodontal examination, responded to questions regarding hormone replacement therapy (HRT) and provided a blood sample for serum vitamin D assessments. For mechanistic cell culture studies, human monocytes were cultured with or without LPS,... (More)
- Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes cross-sectional data from the continuous NHANES 2001-2004. The cross-sections include n=1,230 women aged 40-85 who received a periodontal examination, responded to questions regarding hormone replacement therapy (HRT) and provided a blood sample for serum vitamin D assessments. For mechanistic cell culture studies, human monocytes were cultured with or without LPS, estradiol, progesterone and/or 1,25-dihydroxyvitamin D3 and transcriptional activity of IL-6, IL-1β, BLC and RANTES was assessed. Results: HRT use (vs. none) was associated with higher attachment levels and more teeth only among vitamin D sufficient (>20 ng/ml) participants. The odds ratio for having moderate/severe periodontitis among HRT vs. non-HRT users was 0.69 among vitamin D sufficient participants and 1.19 in vitamin D deficient subjects. LPS-induced IL-6, IL-1β and BLC expression was attenuated in human monocytes treated with estrogen and progesterone. Down-regulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included. LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Conclusion: Maximal beneficial effects of HRT on periodontitis are associated with high vitamin D levels. This effect is plausibly mediated via an anti-inflammatory transcriptional mechanism. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3161199
- author
- Jönsson, Daniel LU ; Aggarwal, Prerna ; Nilsson, Bengt-Olof LU and Demmer, Ryan T
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Periodontology
- volume
- 84
- issue
- 8
- pages
- 1048 - 1057
- publisher
- American Academy of Periodontology
- external identifiers
-
- wos:000328685100002
- pmid:23030238
- scopus:84882242816
- pmid:23030238
- ISSN
- 0022-3492
- DOI
- 10.1902/jop.2012.120434
- language
- English
- LU publication?
- yes
- id
- 2105c6e5-2aad-47c6-9d1d-158a5255a6e0 (old id 3161199)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23030238?dopt=Abstract
- date added to LUP
- 2016-04-01 10:22:52
- date last changed
- 2022-03-19 20:09:49
@article{2105c6e5-2aad-47c6-9d1d-158a5255a6e0, abstract = {{Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes cross-sectional data from the continuous NHANES 2001-2004. The cross-sections include n=1,230 women aged 40-85 who received a periodontal examination, responded to questions regarding hormone replacement therapy (HRT) and provided a blood sample for serum vitamin D assessments. For mechanistic cell culture studies, human monocytes were cultured with or without LPS, estradiol, progesterone and/or 1,25-dihydroxyvitamin D3 and transcriptional activity of IL-6, IL-1β, BLC and RANTES was assessed. Results: HRT use (vs. none) was associated with higher attachment levels and more teeth only among vitamin D sufficient (>20 ng/ml) participants. The odds ratio for having moderate/severe periodontitis among HRT vs. non-HRT users was 0.69 among vitamin D sufficient participants and 1.19 in vitamin D deficient subjects. LPS-induced IL-6, IL-1β and BLC expression was attenuated in human monocytes treated with estrogen and progesterone. Down-regulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included. LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Conclusion: Maximal beneficial effects of HRT on periodontitis are associated with high vitamin D levels. This effect is plausibly mediated via an anti-inflammatory transcriptional mechanism.}}, author = {{Jönsson, Daniel and Aggarwal, Prerna and Nilsson, Bengt-Olof and Demmer, Ryan T}}, issn = {{0022-3492}}, language = {{eng}}, number = {{8}}, pages = {{1048--1057}}, publisher = {{American Academy of Periodontology}}, series = {{Journal of Periodontology}}, title = {{Beneficial Effects of Hormone Replacement Therapy on Periodontitis are Vitamin D Associated.}}, url = {{http://dx.doi.org/10.1902/jop.2012.120434}}, doi = {{10.1902/jop.2012.120434}}, volume = {{84}}, year = {{2013}}, }