Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease
(2013) In Lancet Neurology 12(1). p.84-91- Abstract
- Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease was first done more than 20 years ago. Since then, many patients have received transplants, with variable results. During this time, our knowledge of Parkinson's disease has changed and the nature and extent of problems associated with the disorder have been better defined. Our understanding on how best to implement this cell-replacement strategy for patients has grown, but gaining this insight has entailed critical reappraisal of data from transplant trials that have already been undertaken.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3400884
- author
- Barker, Roger LU ; Barrett, Jessica ; Mason, Sarah L. and Björklund, Anders LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Lancet Neurology
- volume
- 12
- issue
- 1
- pages
- 84 - 91
- publisher
- Lancet Publishing Group
- external identifiers
-
- wos:000312429400023
- scopus:84870772482
- ISSN
- 1474-4465
- DOI
- 10.1016/S1474-4422(12)70295-8
- language
- English
- LU publication?
- yes
- id
- 1058be8c-f6d1-4457-9190-ba708e504878 (old id 3400884)
- date added to LUP
- 2016-04-01 10:28:29
- date last changed
- 2022-05-13 17:12:17
@article{1058be8c-f6d1-4457-9190-ba708e504878, abstract = {{Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease was first done more than 20 years ago. Since then, many patients have received transplants, with variable results. During this time, our knowledge of Parkinson's disease has changed and the nature and extent of problems associated with the disorder have been better defined. Our understanding on how best to implement this cell-replacement strategy for patients has grown, but gaining this insight has entailed critical reappraisal of data from transplant trials that have already been undertaken.}}, author = {{Barker, Roger and Barrett, Jessica and Mason, Sarah L. and Björklund, Anders}}, issn = {{1474-4465}}, language = {{eng}}, number = {{1}}, pages = {{84--91}}, publisher = {{Lancet Publishing Group}}, series = {{Lancet Neurology}}, title = {{Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease}}, url = {{http://dx.doi.org/10.1016/S1474-4422(12)70295-8}}, doi = {{10.1016/S1474-4422(12)70295-8}}, volume = {{12}}, year = {{2013}}, }