APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.
(2013) In Journal of Thrombosis and Thrombolysis 36(4). p.495-500- Abstract
- To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis.... (More)
- To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis. APC-PCI levels were higher in patients with AAA, and showed high sensitivity but low specificity for the diagnosis and can therefore not be considered as a screening tool in PAD patients. An AAA prevalence of 13 % in patients with PAD indicates a need for AAA screening within this population. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3438244
- author
- Zarrouk, Moncef LU ; Keshavarz, Kave ; Lindblad, Bengt LU and Gottsäter, Anders LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Thrombosis and Thrombolysis
- volume
- 36
- issue
- 4
- pages
- 495 - 500
- publisher
- Springer
- external identifiers
-
- wos:000326802500019
- pmid:23354969
- scopus:84889085476
- pmid:23354969
- ISSN
- 1573-742X
- DOI
- 10.1007/s11239-013-0871-6
- language
- English
- LU publication?
- yes
- id
- 6ba55999-c88f-4bb2-b4a1-e80328fa7bb3 (old id 3438244)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23354969?dopt=Abstract
- date added to LUP
- 2016-04-01 09:48:20
- date last changed
- 2022-01-25 08:53:16
@article{6ba55999-c88f-4bb2-b4a1-e80328fa7bb3, abstract = {{To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11 %, a sensitivity of 97 % and a negative predictive value of 96 % for an AAA diagnosis. APC-PCI levels were higher in patients with AAA, and showed high sensitivity but low specificity for the diagnosis and can therefore not be considered as a screening tool in PAD patients. An AAA prevalence of 13 % in patients with PAD indicates a need for AAA screening within this population.}}, author = {{Zarrouk, Moncef and Keshavarz, Kave and Lindblad, Bengt and Gottsäter, Anders}}, issn = {{1573-742X}}, language = {{eng}}, number = {{4}}, pages = {{495--500}}, publisher = {{Springer}}, series = {{Journal of Thrombosis and Thrombolysis}}, title = {{APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.}}, url = {{http://dx.doi.org/10.1007/s11239-013-0871-6}}, doi = {{10.1007/s11239-013-0871-6}}, volume = {{36}}, year = {{2013}}, }