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Biologically active secondary metabolites from the ascomycete A111-95 - 1. Production, isolation and biological activities

Kopcke, B ; Johansson, M ; Sterner, Olov LU and Anke, H (2002) In Journal of Antibiotics 55(1). p.36-40
Abstract
Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Antibiotics
volume
55
issue
1
pages
36 - 40
publisher
Japan Antibiotics Research Association
external identifiers
  • wos:000173536100006
  • scopus:0036171667
ISSN
0021-8820
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
acdfa526-f459-4807-b105-d72b52d82be6 (old id 344136)
date added to LUP
2016-04-01 15:57:41
date last changed
2022-01-28 08:17:05
@article{acdfa526-f459-4807-b105-d72b52d82be6,
  abstract     = {{Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.}},
  author       = {{Kopcke, B and Johansson, M and Sterner, Olov and Anke, H}},
  issn         = {{0021-8820}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{36--40}},
  publisher    = {{Japan Antibiotics Research Association}},
  series       = {{Journal of Antibiotics}},
  title        = {{Biologically active secondary metabolites from the ascomycete A111-95 - 1. Production, isolation and biological activities}},
  volume       = {{55}},
  year         = {{2002}},
}