Interleukin-6-deficient mice develop mature-onset obesity
(2002) In Nature Medicine 8(1). p.75-79- Abstract
- The immune-modulating cytokine interleukin-6 (IL-6) its expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (116(-/-) mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement: The obese 116(-/-) mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment... (More)
- The immune-modulating cytokine interleukin-6 (IL-6) its expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (116(-/-) mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement: The obese 116(-/-) mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/346358
- author
- Wallenius, V ; Wallenius, K ; Ahrén, Bo LU ; Rudling, M ; Carlsten, H ; Dickson, SL ; Ohlsson, C and Jansson, JO
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 8
- issue
- 1
- pages
- 75 - 79
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:11786910
- wos:000173056900034
- scopus:0036152683
- ISSN
- 1546-170X
- DOI
- 10.1038/nm0102-75
- language
- English
- LU publication?
- yes
- id
- 79a1c99c-7bd3-454c-b297-ce0f285daed4 (old id 346358)
- date added to LUP
- 2016-04-01 15:48:19
- date last changed
- 2024-02-26 07:03:29
@article{79a1c99c-7bd3-454c-b297-ce0f285daed4, abstract = {{The immune-modulating cytokine interleukin-6 (IL-6) its expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (116(-/-) mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement: The obese 116(-/-) mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents.}}, author = {{Wallenius, V and Wallenius, K and Ahrén, Bo and Rudling, M and Carlsten, H and Dickson, SL and Ohlsson, C and Jansson, JO}}, issn = {{1546-170X}}, language = {{eng}}, number = {{1}}, pages = {{75--79}}, publisher = {{Nature Publishing Group}}, series = {{Nature Medicine}}, title = {{Interleukin-6-deficient mice develop mature-onset obesity}}, url = {{http://dx.doi.org/10.1038/nm0102-75}}, doi = {{10.1038/nm0102-75}}, volume = {{8}}, year = {{2002}}, }