Operator auditory perception and spectral quantification of umbilical artery Doppler ultrasound signals
(2013) In PLoS ONE 8(5).- Abstract
OBJECTIVE: An experienced sonographer can by listening to the Doppler audio signals perceive various timbres that distinguish different types of umbilical artery flow despite an unchanged pulsatility index (PI). Our aim was to develop an objective measure of the Doppler audio signals recorded from fetoplacental circulation in a sheep model.
METHODS: Various degrees of pathological flow velocity waveforms in the umbilical artery, similar to those in human complicated pregnancies, were induced by microsphere embolization of the placental bed (embolization model, 7 lamb fetuses, 370 Doppler recordings) or by fetal hemodilution (anemia model, 4 lamb fetuses, 184 recordings). A subjective 11-step operator auditory scale (OAS) was... (More)
OBJECTIVE: An experienced sonographer can by listening to the Doppler audio signals perceive various timbres that distinguish different types of umbilical artery flow despite an unchanged pulsatility index (PI). Our aim was to develop an objective measure of the Doppler audio signals recorded from fetoplacental circulation in a sheep model.
METHODS: Various degrees of pathological flow velocity waveforms in the umbilical artery, similar to those in human complicated pregnancies, were induced by microsphere embolization of the placental bed (embolization model, 7 lamb fetuses, 370 Doppler recordings) or by fetal hemodilution (anemia model, 4 lamb fetuses, 184 recordings). A subjective 11-step operator auditory scale (OAS) was related to conventional Doppler parameters, PI and time average mean velocity (TAM), and to sound frequency analysis of Doppler signals (sound frequency with the maximum energy content [MAXpeak] and frequency band at maximum level minus 15 dB [MAXpeak-15 dB] over several heart cycles).
RESULTS: WE FOUND A NEGATIVE CORRELATION BETWEEN THE OAS AND PI: median Rho -0.73 (range -0.35- -0.94) and -0.68 (range -0.57- -0.78) in the two lamb models, respectively. There was a positive correlation between OAS and TAM in both models: median Rho 0.80 (range 0.58-0.95) and 0.90 (range 0.78-0.95), respectively. A strong correlation was found between TAM and the results of sound spectrum analysis; in the embolization model the median r was 0.91 (range 0.88-0.97) for MAXpeak and 0.91 (range 0.82-0.98) for MAXpeak-15 dB. In the anemia model, the corresponding values were 0.92 (range 0.78-0.96) and 0.96 (range 0.89-0.98), respectively.
CONCLUSION: Audio-spectrum analysis reflects the subjective perception of Doppler sound signals in the umbilical artery and has a strong correlation to TAM-velocity. This information might be of importance for clinical management of complicated pregnancies as an addition to conventional Doppler parameters.
(Less)
- author
- Thuring, Ann LU ; Brännström, Jonas LU ; Ewerlöf, Maria ; Hernandez-Andrade, Edgar LU ; Ley, David LU ; Lingman, Göran LU ; Liuba, Karina LU ; Marsal, Karel LU and Jansson, Tomas LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Auditory Perception, Blood Flow Velocity, Female, Fetal Growth Retardation/diagnostic imaging, Fetal Hypoxia/diagnostic imaging, Fetus/blood supply, Humans, Medical Laboratory Personnel, Placental Circulation, Pregnancy, Sheep, Sound Spectrography, Ultrasonography, Doppler, Color, Ultrasonography, Prenatal/methods, Umbilical Arteries/abnormalities
- in
- PLoS ONE
- volume
- 8
- issue
- 5
- article number
- e64033
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000319966400044
- pmid:23700452
- scopus:84877884801
- pmid:23700452
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0064033
- language
- English
- LU publication?
- yes
- id
- 217b6f34-ba3f-4a36-a40a-b67606fc7a1d (old id 3804234)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23700452?dopt=Abstract
- date added to LUP
- 2016-04-01 13:43:10
- date last changed
- 2022-03-29 08:59:55
@article{217b6f34-ba3f-4a36-a40a-b67606fc7a1d, abstract = {{<p>OBJECTIVE: An experienced sonographer can by listening to the Doppler audio signals perceive various timbres that distinguish different types of umbilical artery flow despite an unchanged pulsatility index (PI). Our aim was to develop an objective measure of the Doppler audio signals recorded from fetoplacental circulation in a sheep model.</p><p>METHODS: Various degrees of pathological flow velocity waveforms in the umbilical artery, similar to those in human complicated pregnancies, were induced by microsphere embolization of the placental bed (embolization model, 7 lamb fetuses, 370 Doppler recordings) or by fetal hemodilution (anemia model, 4 lamb fetuses, 184 recordings). A subjective 11-step operator auditory scale (OAS) was related to conventional Doppler parameters, PI and time average mean velocity (TAM), and to sound frequency analysis of Doppler signals (sound frequency with the maximum energy content [MAXpeak] and frequency band at maximum level minus 15 dB [MAXpeak-15 dB] over several heart cycles).</p><p>RESULTS: WE FOUND A NEGATIVE CORRELATION BETWEEN THE OAS AND PI: median Rho -0.73 (range -0.35- -0.94) and -0.68 (range -0.57- -0.78) in the two lamb models, respectively. There was a positive correlation between OAS and TAM in both models: median Rho 0.80 (range 0.58-0.95) and 0.90 (range 0.78-0.95), respectively. A strong correlation was found between TAM and the results of sound spectrum analysis; in the embolization model the median r was 0.91 (range 0.88-0.97) for MAXpeak and 0.91 (range 0.82-0.98) for MAXpeak-15 dB. In the anemia model, the corresponding values were 0.92 (range 0.78-0.96) and 0.96 (range 0.89-0.98), respectively.</p><p>CONCLUSION: Audio-spectrum analysis reflects the subjective perception of Doppler sound signals in the umbilical artery and has a strong correlation to TAM-velocity. This information might be of importance for clinical management of complicated pregnancies as an addition to conventional Doppler parameters.</p>}}, author = {{Thuring, Ann and Brännström, Jonas and Ewerlöf, Maria and Hernandez-Andrade, Edgar and Ley, David and Lingman, Göran and Liuba, Karina and Marsal, Karel and Jansson, Tomas}}, issn = {{1932-6203}}, keywords = {{Animals; Auditory Perception; Blood Flow Velocity; Female; Fetal Growth Retardation/diagnostic imaging; Fetal Hypoxia/diagnostic imaging; Fetus/blood supply; Humans; Medical Laboratory Personnel; Placental Circulation; Pregnancy; Sheep; Sound Spectrography; Ultrasonography, Doppler, Color; Ultrasonography, Prenatal/methods; Umbilical Arteries/abnormalities}}, language = {{eng}}, number = {{5}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Operator auditory perception and spectral quantification of umbilical artery Doppler ultrasound signals}}, url = {{https://lup.lub.lu.se/search/files/3552363/4064587.pdf}}, doi = {{10.1371/journal.pone.0064033}}, volume = {{8}}, year = {{2013}}, }