Previous SARS-CoV-2 infections and their impact on the protection from reinfection during the Omicron BA.5 wave – a nested case-control study among vaccinated adults in Sweden
(2024) In IJID Regions 10. p.235-239- Abstract
Objectives: We evaluated the protection afforded by SARS-CoV-2 infection-induced immunity against reinfection among working-age vaccinated individuals during a calendar period from June to December 2022 when Omicron BA.5 was the dominating subvariant in Scania County, Sweden. Methods: The study cohort (n = 71,592) mainly consisted of health care workers. We analyzed 4144 infected cases during the Omicron BA.5 dominance and 41,440 sex- and age-matched controls with conditional logistic regression. Results: The average protection against reinfection was marginal (16%, 95% confidence interval [CI] 7-23%) during the study period but substantially higher for recent infections. Recent infection (3-6 months) with Omicron BA.2 and BA.5 offered... (More)
Objectives: We evaluated the protection afforded by SARS-CoV-2 infection-induced immunity against reinfection among working-age vaccinated individuals during a calendar period from June to December 2022 when Omicron BA.5 was the dominating subvariant in Scania County, Sweden. Methods: The study cohort (n = 71,592) mainly consisted of health care workers. We analyzed 4144 infected cases during the Omicron BA.5 dominance and 41,440 sex- and age-matched controls with conditional logistic regression. Results: The average protection against reinfection was marginal (16%, 95% confidence interval [CI] 7-23%) during the study period but substantially higher for recent infections. Recent infection (3-6 months) with Omicron BA.2 and BA.5 offered strong protection (86%, 95% CI 68-94% and 78%, 95% CI 69-84%), whereas more distant infection (6-12 months) with Omicron BA.1, BA.2, and the variants before Omicron offered marginal or no protection. Conclusions: These findings suggest that infection-induced immunity contributes to short-term population protection against infection with the subvariant BA.5 among working-age vaccinated individuals but wanes considerably with time, independent of the virus variant.
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- author
- Kahn, Fredrik LU ; Bonander, Carl ; Moghaddassi, Mahnaz LU ; Christiansen, Claus Bohn ; Bennet, Louise LU ; Malmqvist, Ulf ; Inghammar, Malin LU and Björk, Jonas LU
- organization
-
- Infection Medicine (BMC)
- Neutrophils – new mechanisms and new biomarkers (research group)
- Social Medicine and Global Health (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Family Medicine and Community Medicine (research group)
- EpiHealth: Epidemiology for Health
- LU Profile Area: Nature-based future solutions
- eSSENCE: The e-Science Collaboration
- EPI@LUND (research group)
- Division of Occupational and Environmental Medicine, Lund University
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epidemiological surveillance, SARS-CoV-2 infection, Variant of concern
- in
- IJID Regions
- volume
- 10
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:38532742
- scopus:85187403707
- ISSN
- 2772-7076
- DOI
- 10.1016/j.ijregi.2024.02.004
- project
- Improved preparedness for future pandemics and other health crises through large-scale disease surveillance
- language
- English
- LU publication?
- yes
- id
- 385e7a63-9aed-4b3d-b38b-a068f6769609
- date added to LUP
- 2024-04-09 12:02:03
- date last changed
- 2024-07-18 00:40:40
@article{385e7a63-9aed-4b3d-b38b-a068f6769609, abstract = {{<p>Objectives: We evaluated the protection afforded by SARS-CoV-2 infection-induced immunity against reinfection among working-age vaccinated individuals during a calendar period from June to December 2022 when Omicron BA.5 was the dominating subvariant in Scania County, Sweden. Methods: The study cohort (n = 71,592) mainly consisted of health care workers. We analyzed 4144 infected cases during the Omicron BA.5 dominance and 41,440 sex- and age-matched controls with conditional logistic regression. Results: The average protection against reinfection was marginal (16%, 95% confidence interval [CI] 7-23%) during the study period but substantially higher for recent infections. Recent infection (3-6 months) with Omicron BA.2 and BA.5 offered strong protection (86%, 95% CI 68-94% and 78%, 95% CI 69-84%), whereas more distant infection (6-12 months) with Omicron BA.1, BA.2, and the variants before Omicron offered marginal or no protection. Conclusions: These findings suggest that infection-induced immunity contributes to short-term population protection against infection with the subvariant BA.5 among working-age vaccinated individuals but wanes considerably with time, independent of the virus variant.</p>}}, author = {{Kahn, Fredrik and Bonander, Carl and Moghaddassi, Mahnaz and Christiansen, Claus Bohn and Bennet, Louise and Malmqvist, Ulf and Inghammar, Malin and Björk, Jonas}}, issn = {{2772-7076}}, keywords = {{Epidemiological surveillance; SARS-CoV-2 infection; Variant of concern}}, language = {{eng}}, pages = {{235--239}}, publisher = {{Elsevier}}, series = {{IJID Regions}}, title = {{Previous SARS-CoV-2 infections and their impact on the protection from reinfection during the Omicron BA.5 wave – a nested case-control study among vaccinated adults in Sweden}}, url = {{http://dx.doi.org/10.1016/j.ijregi.2024.02.004}}, doi = {{10.1016/j.ijregi.2024.02.004}}, volume = {{10}}, year = {{2024}}, }