Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density
(2006) In Environmental Science & Technology 40(20). p.6282-6289- Abstract
- Lack of human exposure data is frequently reported as a critical gap in risk assessments of environmental pollutants, especially regarding "new" pollutants. The objectives of this study were to assess serum levels of the persistent 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecanes (HBCDDs) in a group of Swedish middle-aged and elderly women expected to be relatively highly exposed, and to evaluate the impact of potential determinants (e.g., fish intake, age) for the inter-individual variation, as well as to investigate the association between these pollutants and bone density. No associations were found between bone... (More)
- Lack of human exposure data is frequently reported as a critical gap in risk assessments of environmental pollutants, especially regarding "new" pollutants. The objectives of this study were to assess serum levels of the persistent 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecanes (HBCDDs) in a group of Swedish middle-aged and elderly women expected to be relatively highly exposed, and to evaluate the impact of potential determinants (e.g., fish intake, age) for the inter-individual variation, as well as to investigate the association between these pollutants and bone density. No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants. Relatively high levels of CB-153 (median 260 ng/g fat) and Sigma(3)-OH- PCBs (median 1.7 ng/mL serum), and low concentrations of Sigma 6PBDEs (median 3.6 ng/g fat) were determined. Total level of HBCDDs in serum was quantified by gas chromatography with mass spectrometric detection (median 0.5 ng/g fat). HBCDD diastereomeric and enantiomeric patterns were determined by liquid chromatography with mass spectrometric detection. The dominating stereoisomer was (-)alpha-HBCDD, but 1-3% of gamma-HBCDD was also detected in the serum samples. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/388097
- author
- Weiss, Jana ; Wallin, Ewa LU ; Axmon, Anna LU ; Jönsson, Bo A LU ; Åkesson, Heléne LU ; Janak, Karel ; Hagmar, Lars and Bergman, Ake
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Environmental Science & Technology
- volume
- 40
- issue
- 20
- pages
- 6282 - 6289
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000241192600020
- scopus:33750315245
- ISSN
- 1520-5851
- DOI
- 10.1021/es0610941
- language
- English
- LU publication?
- yes
- id
- d0b1230f-18da-4d68-8e41-f914816b3aa1 (old id 388097)
- date added to LUP
- 2016-04-01 15:41:55
- date last changed
- 2022-03-14 19:32:22
@article{d0b1230f-18da-4d68-8e41-f914816b3aa1, abstract = {{Lack of human exposure data is frequently reported as a critical gap in risk assessments of environmental pollutants, especially regarding "new" pollutants. The objectives of this study were to assess serum levels of the persistent 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecanes (HBCDDs) in a group of Swedish middle-aged and elderly women expected to be relatively highly exposed, and to evaluate the impact of potential determinants (e.g., fish intake, age) for the inter-individual variation, as well as to investigate the association between these pollutants and bone density. No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants. Relatively high levels of CB-153 (median 260 ng/g fat) and Sigma(3)-OH- PCBs (median 1.7 ng/mL serum), and low concentrations of Sigma 6PBDEs (median 3.6 ng/g fat) were determined. Total level of HBCDDs in serum was quantified by gas chromatography with mass spectrometric detection (median 0.5 ng/g fat). HBCDD diastereomeric and enantiomeric patterns were determined by liquid chromatography with mass spectrometric detection. The dominating stereoisomer was (-)alpha-HBCDD, but 1-3% of gamma-HBCDD was also detected in the serum samples.}}, author = {{Weiss, Jana and Wallin, Ewa and Axmon, Anna and Jönsson, Bo A and Åkesson, Heléne and Janak, Karel and Hagmar, Lars and Bergman, Ake}}, issn = {{1520-5851}}, language = {{eng}}, number = {{20}}, pages = {{6282--6289}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Environmental Science & Technology}}, title = {{Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density}}, url = {{http://dx.doi.org/10.1021/es0610941}}, doi = {{10.1021/es0610941}}, volume = {{40}}, year = {{2006}}, }