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Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes

Nilsson, Charlotta LU and Dereke, Jonatan LU orcid (2024) In Journal of Diabetes and Metabolic Disorders 23(1). p.1251-1257
Abstract

Purpose: Complications from diabetes mellitus can occur over time and although glycosylated hemoglobin (HbA1c) is a good biomarker for glycaemic control, other factors also contribute to the development of complications in type 1 diabetes. More markers able to identify the risk of complications are needed. This study aimed to investigate plasma levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 in children and adolescents with different duration of type 1 diabetes and possible correlation to HbA1c to identify potential biomarkers of future complication development. Methods: Patients (n = 244, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital, Sweden, were included in this study. Circulating levels of FGF21, Cystatin C,... (More)

Purpose: Complications from diabetes mellitus can occur over time and although glycosylated hemoglobin (HbA1c) is a good biomarker for glycaemic control, other factors also contribute to the development of complications in type 1 diabetes. More markers able to identify the risk of complications are needed. This study aimed to investigate plasma levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 in children and adolescents with different duration of type 1 diabetes and possible correlation to HbA1c to identify potential biomarkers of future complication development. Methods: Patients (n = 244, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital, Sweden, were included in this study. Circulating levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 were investigated in plasma using automated ELISA with the ELLA™ system and standardised controls. Results: Cystatin C levels were elevated in patients with diabetes duration longer than 5 years (P < 0.001). HbA1c and Cystatin C levels were inversely correlated for all participants (rs = − 0.23, CI95: −0.35-−0.10; P < 0.001). A stepwise multiple regression analysis showed that HbA1c (P < 0.001) and Cystatin C (P = 0.03) were associated to the duration of diabetes at sampling while MMP-9, lipocalin-2, and FGF21 did not reach statistical significance. Conclusion: In conclusion, Cystatin C levels were higher in patients with diabetes duration longer than 5 years, and inverse correlation was found between HbA1c and Cystatin C levels as well as duration of diabetes. Cystatin C may prove useful as an adjunct to HbA1c in predicting eventual development of diabetic complications.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Complications, HbA1c, Proteins, Type 1 diabetes
in
Journal of Diabetes and Metabolic Disorders
volume
23
issue
1
pages
7 pages
publisher
BioMed Central (BMC)
external identifiers
  • pmid:38932813
  • scopus:85190671150
ISSN
2251-6581
DOI
10.1007/s40200-024-01419-1
language
English
LU publication?
yes
id
3a48704e-2d8b-4d90-b0e1-37f4d3ac351c
date added to LUP
2025-01-15 10:21:10
date last changed
2025-07-17 01:21:22
@article{3a48704e-2d8b-4d90-b0e1-37f4d3ac351c,
  abstract     = {{<p>Purpose: Complications from diabetes mellitus can occur over time and although glycosylated hemoglobin (HbA1c) is a good biomarker for glycaemic control, other factors also contribute to the development of complications in type 1 diabetes. More markers able to identify the risk of complications are needed. This study aimed to investigate plasma levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 in children and adolescents with different duration of type 1 diabetes and possible correlation to HbA1c to identify potential biomarkers of future complication development. Methods: Patients (n = 244, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital, Sweden, were included in this study. Circulating levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 were investigated in plasma using automated ELISA with the ELLA™ system and standardised controls. Results: Cystatin C levels were elevated in patients with diabetes duration longer than 5 years (P &lt; 0.001). HbA1c and Cystatin C levels were inversely correlated for all participants (rs = − 0.23, CI95: −0.35-−0.10; P &lt; 0.001). A stepwise multiple regression analysis showed that HbA1c (P &lt; 0.001) and Cystatin C (P = 0.03) were associated to the duration of diabetes at sampling while MMP-9, lipocalin-2, and FGF21 did not reach statistical significance. Conclusion: In conclusion, Cystatin C levels were higher in patients with diabetes duration longer than 5 years, and inverse correlation was found between HbA1c and Cystatin C levels as well as duration of diabetes. Cystatin C may prove useful as an adjunct to HbA1c in predicting eventual development of diabetic complications.</p>}},
  author       = {{Nilsson, Charlotta and Dereke, Jonatan}},
  issn         = {{2251-6581}},
  keywords     = {{Complications; HbA1c; Proteins; Type 1 diabetes}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1251--1257}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Diabetes and Metabolic Disorders}},
  title        = {{Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1007/s40200-024-01419-1}},
  doi          = {{10.1007/s40200-024-01419-1}},
  volume       = {{23}},
  year         = {{2024}},
}