Past, Present, and Future of Direct Cell Reprogramming
(2022) In Cellular Reprogramming 24(5). p.205-211- Abstract
Budding off from the broader developmental biology and stem cell research fields, cellular reprogramming is now established as a prominent discipline in its own right. Direct cell reprogramming is defined as the cell fate conversion of a somatic cell toward another identity without a pluripotent intermediate state. In addition to the opportunity for mechanistic dissection of lineage commitment in human cells, the field offer the promise of diverse applications such as for disease modeling, cell replacement therapy, regenerative medicine, and immunotherapy that have recently spurred innovation and out of the box thinking to unleash the potential of cellular plasticity.
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https://lup.lub.lu.se/record/3d93078f-75c7-478f-9e56-d2d25bf84dc4
- author
- Ahlenius, Henrik LU
- organization
- publishing date
- 2022-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cellular plasticity, direct conversion, direct reprogramming, induced pluripotent stem cells, regenerative medicine, transdifferentiation
- in
- Cellular Reprogramming
- volume
- 24
- issue
- 5
- pages
- 7 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:36219713
- scopus:85139637615
- ISSN
- 2152-4971
- DOI
- 10.1089/cell.2022.0110
- language
- English
- LU publication?
- yes
- id
- 3d93078f-75c7-478f-9e56-d2d25bf84dc4
- date added to LUP
- 2022-12-09 14:04:07
- date last changed
- 2024-09-05 21:06:14
@article{3d93078f-75c7-478f-9e56-d2d25bf84dc4, abstract = {{<p>Budding off from the broader developmental biology and stem cell research fields, cellular reprogramming is now established as a prominent discipline in its own right. Direct cell reprogramming is defined as the cell fate conversion of a somatic cell toward another identity without a pluripotent intermediate state. In addition to the opportunity for mechanistic dissection of lineage commitment in human cells, the field offer the promise of diverse applications such as for disease modeling, cell replacement therapy, regenerative medicine, and immunotherapy that have recently spurred innovation and out of the box thinking to unleash the potential of cellular plasticity.</p>}}, author = {{Ahlenius, Henrik}}, issn = {{2152-4971}}, keywords = {{cellular plasticity; direct conversion; direct reprogramming; induced pluripotent stem cells; regenerative medicine; transdifferentiation}}, language = {{eng}}, month = {{10}}, number = {{5}}, pages = {{205--211}}, publisher = {{Mary Ann Liebert, Inc.}}, series = {{Cellular Reprogramming}}, title = {{Past, Present, and Future of Direct Cell Reprogramming}}, url = {{http://dx.doi.org/10.1089/cell.2022.0110}}, doi = {{10.1089/cell.2022.0110}}, volume = {{24}}, year = {{2022}}, }