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In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state

Krueger, Martin W. ; Dorn, Andreas ; Keller, David U. J. ; Holmqvist, Fredrik LU ; Carlson, Jonas LU orcid ; Platonov, Pyotr LU ; Rhode, Kawal S. ; Razavi, Reza ; Seemann, Gunnar and Doessel, Olaf (2013) In Medical & Biological Engineering & Computing 51(10). p.1105-1119
Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used in in-silico human atrial modeling studies, they have not been thoroughly investigated. In this study, the original electrophysiological (EP) models of Courtemanche et al., Nygren et al. and Maleckar et al. were adjusted to reproduce action potentials in 13 atrial regions. The parameter sets were validated against experimental action potential duration data and ECG data from patients with AV block. The... (More)
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used in in-silico human atrial modeling studies, they have not been thoroughly investigated. In this study, the original electrophysiological (EP) models of Courtemanche et al., Nygren et al. and Maleckar et al. were adjusted to reproduce action potentials in 13 atrial regions. The parameter sets were validated against experimental action potential duration data and ECG data from patients with AV block. The use of the heterogeneous EP model led to a more synchronized repolarization sequence in a variety of 3D atrial anatomical models. Combination of the heterogeneous EP model with a model of persistent AF-remodeled electrophysiology led to a drastic change in cell electrophysiology. Simulated Ta-waves were significantly shorter under the remodeling. The heterogeneities in cell electrophysiology explain the previously observed Ta-wave effects. The results mark an important step toward the reliable simulation of the atrial repolarization sequence, give a deeper understanding of the mechanism of atrial repolarization and enable further clinical investigations. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrial repolarization, Cardiac electrophysiology, Multi-scale cardiac, modeling, Atrial fibrillation, Electrical remodeling
in
Medical & Biological Engineering & Computing
volume
51
issue
10
pages
1105 - 1119
publisher
Springer
external identifiers
  • wos:000323519800004
  • scopus:84896720772
ISSN
0140-0118
DOI
10.1007/s11517-013-1090-1
language
English
LU publication?
yes
id
3cefd36b-fe2a-4f74-93db-915e924e8de7 (old id 4062676)
date added to LUP
2016-04-01 13:03:52
date last changed
2022-01-27 17:06:33
@article{3cefd36b-fe2a-4f74-93db-915e924e8de7,
  abstract     = {{Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used in in-silico human atrial modeling studies, they have not been thoroughly investigated. In this study, the original electrophysiological (EP) models of Courtemanche et al., Nygren et al. and Maleckar et al. were adjusted to reproduce action potentials in 13 atrial regions. The parameter sets were validated against experimental action potential duration data and ECG data from patients with AV block. The use of the heterogeneous EP model led to a more synchronized repolarization sequence in a variety of 3D atrial anatomical models. Combination of the heterogeneous EP model with a model of persistent AF-remodeled electrophysiology led to a drastic change in cell electrophysiology. Simulated Ta-waves were significantly shorter under the remodeling. The heterogeneities in cell electrophysiology explain the previously observed Ta-wave effects. The results mark an important step toward the reliable simulation of the atrial repolarization sequence, give a deeper understanding of the mechanism of atrial repolarization and enable further clinical investigations.}},
  author       = {{Krueger, Martin W. and Dorn, Andreas and Keller, David U. J. and Holmqvist, Fredrik and Carlson, Jonas and Platonov, Pyotr and Rhode, Kawal S. and Razavi, Reza and Seemann, Gunnar and Doessel, Olaf}},
  issn         = {{0140-0118}},
  keywords     = {{Atrial repolarization; Cardiac electrophysiology; Multi-scale cardiac; modeling; Atrial fibrillation; Electrical remodeling}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1105--1119}},
  publisher    = {{Springer}},
  series       = {{Medical & Biological Engineering & Computing}},
  title        = {{In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state}},
  url          = {{http://dx.doi.org/10.1007/s11517-013-1090-1}},
  doi          = {{10.1007/s11517-013-1090-1}},
  volume       = {{51}},
  year         = {{2013}},
}