Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
(2013) In Blood 122(7). p.1284-1292- Abstract
- Clinical management guidelines on malignant disorders are generally based on data from clinical trials with selected patient cohorts. In Sweden, more than 95% of all patients diagnosed with chronic myeloid leukemia (CML) are reported to the national CML registry, providing unique possibilities to compile population-based information. This report is based on registry data from 2002 to 2010, when a total of 779 patients (425 men, 354 women; median age, 60 years) were diagnosed with CML (93% chronic, 5% accelerated, and 2% blastic phase) corresponding to an annual incidence of 0.9/100 000. In 2002, approximately half of the patients received a tyrosine kinase inhibitor as initial therapy, a proportion that increased to 94% for younger (<70... (More)
- Clinical management guidelines on malignant disorders are generally based on data from clinical trials with selected patient cohorts. In Sweden, more than 95% of all patients diagnosed with chronic myeloid leukemia (CML) are reported to the national CML registry, providing unique possibilities to compile population-based information. This report is based on registry data from 2002 to 2010, when a total of 779 patients (425 men, 354 women; median age, 60 years) were diagnosed with CML (93% chronic, 5% accelerated, and 2% blastic phase) corresponding to an annual incidence of 0.9/100 000. In 2002, approximately half of the patients received a tyrosine kinase inhibitor as initial therapy, a proportion that increased to 94% for younger (<70 years) and 79% for older (>80 years) patients during 2007-2009. With a median follow-up of 61 months, the relative survival at 5 years was close to 1.0 for patients younger than 60 years and 0.9 for those aged 60 to 80 years, but only 0.6 for those older than 80 years. At 12 months, 3% had progressed to accelerated or blastic phase. Sokal, but not European Treatment and Outcome Study, high-risk scores were significantly linked to inferior overall and relative survival. Patients living in university vs nonuniversity catchment areas more often received tyrosine kinase inhibitors up front but showed comparable survival. (Less)
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https://lup.lub.lu.se/record/4063457
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 122
- issue
- 7
- pages
- 1284 - 1292
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000323392900028
- scopus:84886776435
- pmid:23843494
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2013-04-495598
- language
- English
- LU publication?
- yes
- id
- 8a93f11b-8651-4486-b1be-f73f21bc1467 (old id 4063457)
- date added to LUP
- 2016-04-01 11:07:42
- date last changed
- 2022-08-20 17:36:49
@article{8a93f11b-8651-4486-b1be-f73f21bc1467, abstract = {{Clinical management guidelines on malignant disorders are generally based on data from clinical trials with selected patient cohorts. In Sweden, more than 95% of all patients diagnosed with chronic myeloid leukemia (CML) are reported to the national CML registry, providing unique possibilities to compile population-based information. This report is based on registry data from 2002 to 2010, when a total of 779 patients (425 men, 354 women; median age, 60 years) were diagnosed with CML (93% chronic, 5% accelerated, and 2% blastic phase) corresponding to an annual incidence of 0.9/100 000. In 2002, approximately half of the patients received a tyrosine kinase inhibitor as initial therapy, a proportion that increased to 94% for younger (<70 years) and 79% for older (>80 years) patients during 2007-2009. With a median follow-up of 61 months, the relative survival at 5 years was close to 1.0 for patients younger than 60 years and 0.9 for those aged 60 to 80 years, but only 0.6 for those older than 80 years. At 12 months, 3% had progressed to accelerated or blastic phase. Sokal, but not European Treatment and Outcome Study, high-risk scores were significantly linked to inferior overall and relative survival. Patients living in university vs nonuniversity catchment areas more often received tyrosine kinase inhibitors up front but showed comparable survival.}}, author = {{Hoglund, Martin and Sandin, Fredrik and Hellstrom, Karin and Bjoreman, Mats and Bjorkholm, Magnus and Brune, Mats and Dreimane, Arta and Ekblom, Marja and Lehmann, Soren and Ljungman, Per and Malm, Claes and Markevarn, Berit and Myhr-Eriksson, Kristina and Ohm, Lotta and Olsson-Stromberg, Ulla and Sjalander, Anders and Wadenvik, Hans and Simonsson, Bengt and Stenke, Leif and Richter, Johan}}, issn = {{1528-0020}}, language = {{eng}}, number = {{7}}, pages = {{1284--1292}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry}}, url = {{http://dx.doi.org/10.1182/blood-2013-04-495598}}, doi = {{10.1182/blood-2013-04-495598}}, volume = {{122}}, year = {{2013}}, }