Different patterns in immunoreactive anionic and cationic trypsinogen in urine and serum in human acute pancreatitis
(1999) In International Journal of Pancreatology 25(3). p.165-170- Abstract
- BACKGROUND:
Acute pancreatitis (AP) results in elevated concentrations of trypsinogen (T) isoenzymes in serum. Immunoreactive anionic trypsinogen in urin (irAT/u) is elevated in AP, and has recently been proposed as a rapid diagnostic instrument and severity predictor. These results have not been confirmed by other groups, and irAT/u has not been further characterized. The concentration of immunoreactive cationic trypsinogen in urine (irCT/u) and the serum irAT/irCT ratio in AP have not been extensively examined.
METHODS:
Levels of irAT and irCT were studied in urine and serum from 50 AP patients and in urine from 41 non-AP patients. Severity was assessed according to the Atlanta... (More) - BACKGROUND:
Acute pancreatitis (AP) results in elevated concentrations of trypsinogen (T) isoenzymes in serum. Immunoreactive anionic trypsinogen in urin (irAT/u) is elevated in AP, and has recently been proposed as a rapid diagnostic instrument and severity predictor. These results have not been confirmed by other groups, and irAT/u has not been further characterized. The concentration of immunoreactive cationic trypsinogen in urine (irCT/u) and the serum irAT/irCT ratio in AP have not been extensively examined.
METHODS:
Levels of irAT and irCT were studied in urine and serum from 50 AP patients and in urine from 41 non-AP patients. Severity was assessed according to the Atlanta classification. irAT/u was characterized by gel filtration.
RESULTS:
Gel filtration revealed only AT in the urine. Highly significant differences in irAT/u were seen between AP/non-AP (p < 0.0001) and mild/severe disease (p = 0.0012). The irAT/irCT ratio in serum changed from normal 0.8 to 1.3 in AP.
CONCLUSIONS:
IrAT and only traces of irCT were found in the urine in AP. IrAT/u was higher in AP than in other acute abdominal disorders (non-AP) and also higher in severe than in mild AP. IrAT in serum (irAT/s) increased proportionally more than irCT/s in AP, but did not discriminate mild from severe forms. High levels of irAT/u in some non-AP cases and a wide range in AP cases make the clinical value of the test questionable. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4139585
- author
- Petersson, Ulf LU ; Appelros, Stefan LU and Borgström, Anders LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Pancreatology
- volume
- 25
- issue
- 3
- pages
- 165 - 170
- publisher
- Humana Press
- external identifiers
-
- scopus:0032800331
- ISSN
- 0169-4197
- language
- English
- LU publication?
- yes
- id
- a48d9f9f-76bc-4e42-b515-747b65182060 (old id 4139585)
- alternative location
- http://link.springer.com/article/10.1007/BF02925965
- date added to LUP
- 2016-04-01 16:44:14
- date last changed
- 2022-01-28 21:45:00
@article{a48d9f9f-76bc-4e42-b515-747b65182060, abstract = {{BACKGROUND: <br/><br> <br/><br> Acute pancreatitis (AP) results in elevated concentrations of trypsinogen (T) isoenzymes in serum. Immunoreactive anionic trypsinogen in urin (irAT/u) is elevated in AP, and has recently been proposed as a rapid diagnostic instrument and severity predictor. These results have not been confirmed by other groups, and irAT/u has not been further characterized. The concentration of immunoreactive cationic trypsinogen in urine (irCT/u) and the serum irAT/irCT ratio in AP have not been extensively examined.<br/><br> <br/><br> METHODS: <br/><br> <br/><br> Levels of irAT and irCT were studied in urine and serum from 50 AP patients and in urine from 41 non-AP patients. Severity was assessed according to the Atlanta classification. irAT/u was characterized by gel filtration.<br/><br> <br/><br> RESULTS: <br/><br> <br/><br> Gel filtration revealed only AT in the urine. Highly significant differences in irAT/u were seen between AP/non-AP (p < 0.0001) and mild/severe disease (p = 0.0012). The irAT/irCT ratio in serum changed from normal 0.8 to 1.3 in AP.<br/><br> <br/><br> CONCLUSIONS: <br/><br> <br/><br> IrAT and only traces of irCT were found in the urine in AP. IrAT/u was higher in AP than in other acute abdominal disorders (non-AP) and also higher in severe than in mild AP. IrAT in serum (irAT/s) increased proportionally more than irCT/s in AP, but did not discriminate mild from severe forms. High levels of irAT/u in some non-AP cases and a wide range in AP cases make the clinical value of the test questionable.}}, author = {{Petersson, Ulf and Appelros, Stefan and Borgström, Anders}}, issn = {{0169-4197}}, language = {{eng}}, number = {{3}}, pages = {{165--170}}, publisher = {{Humana Press}}, series = {{International Journal of Pancreatology}}, title = {{Different patterns in immunoreactive anionic and cationic trypsinogen in urine and serum in human acute pancreatitis}}, url = {{http://link.springer.com/article/10.1007/BF02925965}}, volume = {{25}}, year = {{1999}}, }