Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study
(2013) In Annals of Clinical Biochemistry 50(6). p.585-594- Abstract
- Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered a better marker for early cobalamin depletion than total cobalamin. However, in elderly populations, health-related reference intervals for holoTC and correlations to renal function are not entirely clear. Methods HoloTC was determined with an automated microparticle enzyme immunoassay (AxSYM (R)) in 790 elderly non-vitamin-supplemented Swedish men, median age 75.3 years. Renal function was assessed with creatinine, cystatin C and estimated glomerular filtration rate (eGFR calculated from... (More)
- Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered a better marker for early cobalamin depletion than total cobalamin. However, in elderly populations, health-related reference intervals for holoTC and correlations to renal function are not entirely clear. Methods HoloTC was determined with an automated microparticle enzyme immunoassay (AxSYM (R)) in 790 elderly non-vitamin-supplemented Swedish men, median age 75.3 years. Renal function was assessed with creatinine, cystatin C and estimated glomerular filtration rate (eGFR calculated from creatinine). Results Median holoTC was 51.8pmol/L, the health-related reference interval 19.6-132.3pmol/L. There was no significant difference in mean holoTC in probands with normal compared to high creatinine (P=0.80) and cystatin C (P=0.82). No significant differences between the quartiles of creatinine or cystatin C in mean of log holoTC were seen. HoloTC correlated strongly with total cobalamin (r=0.69, P<0.001), weaker with eGFR(creatinine) (r=-0.09, P<0.05) and creatinine (r=0.09, P<0.05), the latter correlation was only seen in subjects with creatinine <100 mu mol/L. HoloTC correlated negatively with plasma total homocysteine (r=-0.24, P<0.001), but not with cystatin C and age. Conclusions Serum holoTC in healthy elderly men shows the same distribution as earlier described for a younger reference population. In this group of elderly subjects, holoTC did not correlate to reduced renal function. Thus, holoTC appears to be a promising tool for evaluating cobalamin status also in elderly populations. (Less)
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https://lup.lub.lu.se/record/4157948
- author
- Lewerin, Catharina ; Nilsson-Ehle, Herman ; Jacobsson, Stefan ; Karlsson, Magnus LU ; Ohlsson, Claes and Mellstrom, Dan
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Creatinine, analytes, nutrition, clinical studies, evaluation of new, methods, laboratory methods
- in
- Annals of Clinical Biochemistry
- volume
- 50
- issue
- 6
- pages
- 585 - 594
- publisher
- SAGE Publications
- external identifiers
-
- wos:000325928400009
- scopus:84891883676
- pmid:23901143
- ISSN
- 0004-5632
- DOI
- 10.1177/0004563212474939
- language
- English
- LU publication?
- yes
- id
- ccc7918d-ead8-4176-82e5-5bbb05da6991 (old id 4157948)
- date added to LUP
- 2016-04-01 14:41:26
- date last changed
- 2022-01-28 01:58:12
@article{ccc7918d-ead8-4176-82e5-5bbb05da6991,
abstract = {{Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered a better marker for early cobalamin depletion than total cobalamin. However, in elderly populations, health-related reference intervals for holoTC and correlations to renal function are not entirely clear. Methods HoloTC was determined with an automated microparticle enzyme immunoassay (AxSYM (R)) in 790 elderly non-vitamin-supplemented Swedish men, median age 75.3 years. Renal function was assessed with creatinine, cystatin C and estimated glomerular filtration rate (eGFR calculated from creatinine). Results Median holoTC was 51.8pmol/L, the health-related reference interval 19.6-132.3pmol/L. There was no significant difference in mean holoTC in probands with normal compared to high creatinine (P=0.80) and cystatin C (P=0.82). No significant differences between the quartiles of creatinine or cystatin C in mean of log holoTC were seen. HoloTC correlated strongly with total cobalamin (r=0.69, P<0.001), weaker with eGFR(creatinine) (r=-0.09, P<0.05) and creatinine (r=0.09, P<0.05), the latter correlation was only seen in subjects with creatinine <100 mu mol/L. HoloTC correlated negatively with plasma total homocysteine (r=-0.24, P<0.001), but not with cystatin C and age. Conclusions Serum holoTC in healthy elderly men shows the same distribution as earlier described for a younger reference population. In this group of elderly subjects, holoTC did not correlate to reduced renal function. Thus, holoTC appears to be a promising tool for evaluating cobalamin status also in elderly populations.}},
author = {{Lewerin, Catharina and Nilsson-Ehle, Herman and Jacobsson, Stefan and Karlsson, Magnus and Ohlsson, Claes and Mellstrom, Dan}},
issn = {{0004-5632}},
keywords = {{Creatinine; analytes; nutrition; clinical studies; evaluation of new; methods; laboratory methods}},
language = {{eng}},
number = {{6}},
pages = {{585--594}},
publisher = {{SAGE Publications}},
series = {{Annals of Clinical Biochemistry}},
title = {{Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study}},
url = {{http://dx.doi.org/10.1177/0004563212474939}},
doi = {{10.1177/0004563212474939}},
volume = {{50}},
year = {{2013}},
}