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The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

Mierau, V ; de la Parra, Veronica LU ; Sterner, Olov LU and Anke, T (2006) In Journal of Antibiotics 59(1). p.53-56
Abstract
In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
activities, cytotoxic, Dasyscyphus niveus, niveulone, dasyscyphins, A similar to C
in
Journal of Antibiotics
volume
59
issue
1
pages
53 - 56
publisher
Japan Antibiotics Research Association
external identifiers
  • pmid:16568719
  • wos:000235298300008
  • scopus:33644555234
ISSN
0021-8820
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
0cc4822f-2c4a-4056-996c-4e1b5085d51d (old id 417817)
alternative location
http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article
date added to LUP
2016-04-01 15:33:38
date last changed
2022-01-28 05:54:37
@article{0cc4822f-2c4a-4056-996c-4e1b5085d51d,
  abstract     = {{In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).}},
  author       = {{Mierau, V and de la Parra, Veronica and Sterner, Olov and Anke, T}},
  issn         = {{0021-8820}},
  keywords     = {{activities; cytotoxic; Dasyscyphus niveus; niveulone; dasyscyphins; A similar to C}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{53--56}},
  publisher    = {{Japan Antibiotics Research Association}},
  series       = {{Journal of Antibiotics}},
  title        = {{The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus}},
  url          = {{http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article}},
  volume       = {{59}},
  year         = {{2006}},
}