The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
Aguado, T ; Palazuelos, J ; Monory, K ; Stella, N ; Cravatt, B ; Lutz, B ; Marsicano, G ; Kokaia, Zaal LU
; Guzman, M
and Galve-Roperh, I
(2006)
In The Journal of Neuroscience
26(5).
p.1551-1561
- Abstract
- Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase are expressed, both in vitro and in vivo, in postnatal radial glia (RC2(+) cells) and in adult nestin type I (nestin (+)GFAP(+)) neural progenitor cells. Cell culture experiments show that CB1 receptor activation increases progenitor proliferation and differentiation into astroglial cells in... (More)
- Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase are expressed, both in vitro and in vivo, in postnatal radial glia (RC2(+) cells) and in adult nestin type I (nestin (+)GFAP(+)) neural progenitor cells. Cell culture experiments show that CB1 receptor activation increases progenitor proliferation and differentiation into astroglial cells in vitro. In vivo analysis evidences that, in postnatal CB1-/- mouse brain, progenitor proliferation and astrogliogenesis are impaired. Likewise, in adult CB1-deficient mice, neural progenitor proliferation is decreased but is increased in fatty acid amide hydrolase-deficient mice. In addition, endocannabinoid signaling controls neural progenitor differentiation in the adult brain by promoting astroglial differentiation of newly born cells. These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/418124
- author
- Aguado, T
; Palazuelos, J
; Monory, K
; Stella, N
; Cravatt, B
; Lutz, B
; Marsicano, G
; Kokaia, Zaal
LU
; Guzman, M
and Galve-Roperh, I
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glia, CB1 receptor, radial, astrogliogenesis, proliferation, cannabinoid, neural progenitor
- in
- The Journal of Neuroscience
- volume
- 26
- issue
- 5
- pages
- 1551 - 1561
- publisher
- Society for Neuroscience
- external identifiers
-
- pmid:16452678
- wos:000235043800023
- scopus:32544441379
- pmid:16452678
- ISSN
- 1529-2401
- DOI
- 10.1523/JNEUROSCI.3101-05.2006
- language
- English
- LU publication?
- yes
- id
- a60c4e7c-0670-486a-b2ba-75d6cc70e7b8 (old id 418124)
- date added to LUP
- 2016-04-01 16:24:17
- date last changed
- 2023-10-16 21:12:42
@article{a60c4e7c-0670-486a-b2ba-75d6cc70e7b8,
abstract = {{Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase are expressed, both in vitro and in vivo, in postnatal radial glia (RC2(+) cells) and in adult nestin type I (nestin (+)GFAP(+)) neural progenitor cells. Cell culture experiments show that CB1 receptor activation increases progenitor proliferation and differentiation into astroglial cells in vitro. In vivo analysis evidences that, in postnatal CB1-/- mouse brain, progenitor proliferation and astrogliogenesis are impaired. Likewise, in adult CB1-deficient mice, neural progenitor proliferation is decreased but is increased in fatty acid amide hydrolase-deficient mice. In addition, endocannabinoid signaling controls neural progenitor differentiation in the adult brain by promoting astroglial differentiation of newly born cells. These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function.}},
author = {{Aguado, T and Palazuelos, J and Monory, K and Stella, N and Cravatt, B and Lutz, B and Marsicano, G and Kokaia, Zaal and Guzman, M and Galve-Roperh, I}},
issn = {{1529-2401}},
keywords = {{glia; CB1 receptor; radial; astrogliogenesis; proliferation; cannabinoid; neural progenitor}},
language = {{eng}},
number = {{5}},
pages = {{1551--1561}},
publisher = {{Society for Neuroscience}},
series = {{The Journal of Neuroscience}},
title = {{The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells}},
url = {{http://dx.doi.org/10.1523/JNEUROSCI.3101-05.2006}},
doi = {{10.1523/JNEUROSCI.3101-05.2006}},
volume = {{26}},
year = {{2006}},
}