The association between sociodemographic characteristics and dementia in patients with atrial fibrillation
(2020) In Aging clinical and experimental research 32(11). p.2319-2327- Abstract
Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regression with hazard ratios (HR) and 95% confidence intervals (CI) was used for the association between exposure and outcome, adjusting for age and comorbidities. Results: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up (mean 5.4 years). Of these, 14,097 were men (4.9%) and 16,235 were women (6.5%). Lower educational... (More)
Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regression with hazard ratios (HR) and 95% confidence intervals (CI) was used for the association between exposure and outcome, adjusting for age and comorbidities. Results: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up (mean 5.4 years). Of these, 14,097 were men (4.9%) and 16,235 were women (6.5%). Lower educational levels (reference: highest level) were associated with increased dementia, HRs (95% CI) for basic school for men 1.23 (1.18–1.29) and women 1.36 (1.30–1.42), and middle-level school for men 1.17 (1.11–1.22) and women 1.28 (1.22–1.34). Divorced men and women (reference: married) showed increased risk of dementia, HR 1.07 (1.01–1.13) and 1.12 (1.06–1.18), respectively, while widowed men showed lower risk, HR 0.84 (0.80–0.88). High deprivation neighborhood socio-economic status (NSES; reference: medium level) was associated with increased dementia in men, HR 1.11 (1.05–1.17), and low deprivation neighborhood socio-economic status (NSES) with increased dementia in men and women, HR 1.12 (1.06–1.18) and 1.18 (1.12–1.24), respectively. Conclusions: Some results were expected, i.e. association between lower educational level and dementia. The higher risk of dementia in low deprivation NSES-areas could be due to a higher awareness about dementia, and subsequent earlier diagnosis and treatment of dementia.
(Less)
- author
- Wändell, Per LU ; Carlsson, Axel C. ; Li, Xinjun LU ; Gasevic, Danijela ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atrial fibrillation, Dementia, Gender, Marital status, Socio-economic factors
- in
- Aging clinical and experimental research
- volume
- 32
- issue
- 11
- pages
- 9 pages
- publisher
- Kurtis
- external identifiers
-
- pmid:31927710
- scopus:85077906678
- ISSN
- 1594-0667
- DOI
- 10.1007/s40520-019-01449-3
- language
- English
- LU publication?
- yes
- id
- 418778c9-d954-4624-917f-403163aa016d
- date added to LUP
- 2021-01-04 12:00:21
- date last changed
- 2024-09-19 12:32:18
@article{418778c9-d954-4624-917f-403163aa016d,
abstract = {{<p>Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regression with hazard ratios (HR) and 95% confidence intervals (CI) was used for the association between exposure and outcome, adjusting for age and comorbidities. Results: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up (mean 5.4 years). Of these, 14,097 were men (4.9%) and 16,235 were women (6.5%). Lower educational levels (reference: highest level) were associated with increased dementia, HRs (95% CI) for basic school for men 1.23 (1.18–1.29) and women 1.36 (1.30–1.42), and middle-level school for men 1.17 (1.11–1.22) and women 1.28 (1.22–1.34). Divorced men and women (reference: married) showed increased risk of dementia, HR 1.07 (1.01–1.13) and 1.12 (1.06–1.18), respectively, while widowed men showed lower risk, HR 0.84 (0.80–0.88). High deprivation neighborhood socio-economic status (NSES; reference: medium level) was associated with increased dementia in men, HR 1.11 (1.05–1.17), and low deprivation neighborhood socio-economic status (NSES) with increased dementia in men and women, HR 1.12 (1.06–1.18) and 1.18 (1.12–1.24), respectively. Conclusions: Some results were expected, i.e. association between lower educational level and dementia. The higher risk of dementia in low deprivation NSES-areas could be due to a higher awareness about dementia, and subsequent earlier diagnosis and treatment of dementia.</p>}},
author = {{Wändell, Per and Carlsson, Axel C. and Li, Xinjun and Gasevic, Danijela and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1594-0667}},
keywords = {{Atrial fibrillation; Dementia; Gender; Marital status; Socio-economic factors}},
language = {{eng}},
number = {{11}},
pages = {{2319--2327}},
publisher = {{Kurtis}},
series = {{Aging clinical and experimental research}},
title = {{The association between sociodemographic characteristics and dementia in patients with atrial fibrillation}},
url = {{http://dx.doi.org/10.1007/s40520-019-01449-3}},
doi = {{10.1007/s40520-019-01449-3}},
volume = {{32}},
year = {{2020}},
}