Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity
Kabir, Nuzhat N. and Kazi, Julhash U. LU
(2011)
In Genetics and Molecular Biology
34(4).
p.587-591
- Abstract
- Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases... (More)
- Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4250273
- author
- Kabir, Nuzhat N.
and Kazi, Julhash U.
LU
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aPK, bovine, ePK, kinome
- in
- Genetics and Molecular Biology
- volume
- 34
- issue
- 4
- pages
- 587 - 591
- publisher
- Sociedade Brasileira de Genética
- external identifiers
-
- scopus:82355164475
- ISSN
- 1678-4685
- DOI
- 10.1590/S1415-47572011005000035
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
- id
- 0f4b37d2-a309-4c4d-903c-2e73f5e1223a (old id 4250273)
- alternative location
- https://www.researchgate.net/publication/51981555_Comparative_analysis_of_human_and_bovine_protein_kinases_reveals_unique_relationship_and_functional_diversity/file/d912f511d2257b7f69.pdf?origin=publication_detail
- date added to LUP
- 2016-04-04 13:15:19
- date last changed
- 2022-01-29 23:57:20
@article{0f4b37d2-a309-4c4d-903c-2e73f5e1223a,
abstract = {{Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.}},
author = {{Kabir, Nuzhat N. and Kazi, Julhash U.}},
issn = {{1678-4685}},
keywords = {{aPK; bovine; ePK; kinome}},
language = {{eng}},
number = {{4}},
pages = {{587--591}},
publisher = {{Sociedade Brasileira de Genética}},
series = {{Genetics and Molecular Biology}},
title = {{Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity}},
url = {{https://lup.lub.lu.se/search/files/6078865/4250509.pdf}},
doi = {{10.1590/S1415-47572011005000035}},
volume = {{34}},
year = {{2011}},
}