Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice
(2014) In Pharmaceutical Biology 52(2). p.144-150- Abstract
- Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 +/- 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z.... (More)
- Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 +/- 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z. officinale-treated group) similarly treated as the first batch in addition to the antacid ranitidine (30 mg/kg) 1 h before extract administration. Safety, worm recovery, tissues egg load and oogram pattern were assessed. Results: Calotropis procera latex and flower extracts are toxic (50-70% mortality) even in a small dose (250 mg/kg) before washing off their toxic rubber. Zingiber officinale extract insignificantly decrease (7.26%) S. mansoni worms. When toxic rubber was washed off and ranitidine was used, C. procera (stem latex and flowers) and F. elastica extracts revealed significant S. mansoni worm reductions by 45.31, 53.7 and 16.71%, respectively. Moreover, C. procera extracts produced significant reductions in tissue egg load (similar to 34-38.5%) and positively affected oogram pattern. Conclusion: The present study may be useful to supplement information with regard to C. procera and F. elastica antischistosomal activity and provide a basis for further experimental trials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4326995
- author
- el-Din, Sayed H. Seif ; El-Lakkany, Naglaa M. ; Mohamed, Mona A. ; Hamed, Manal M. ; Sterner, Olov LU and Botros, Sanaa S.
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Asclepiadaceae, moraceae, oogram pattern, tissue egg load, worm burden, zingiberaceae
- in
- Pharmaceutical Biology
- volume
- 52
- issue
- 2
- pages
- 144 - 150
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000329301800002
- scopus:84891776975
- pmid:24047470
- ISSN
- 1744-5116
- DOI
- 10.3109/13880209.2013.818041
- language
- English
- LU publication?
- yes
- id
- c7817a6a-29a8-4927-b327-ffbfd8e19296 (old id 4326995)
- date added to LUP
- 2016-04-01 10:30:45
- date last changed
- 2022-04-20 02:56:24
@article{c7817a6a-29a8-4927-b327-ffbfd8e19296,
abstract = {{Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 +/- 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z. officinale-treated group) similarly treated as the first batch in addition to the antacid ranitidine (30 mg/kg) 1 h before extract administration. Safety, worm recovery, tissues egg load and oogram pattern were assessed. Results: Calotropis procera latex and flower extracts are toxic (50-70% mortality) even in a small dose (250 mg/kg) before washing off their toxic rubber. Zingiber officinale extract insignificantly decrease (7.26%) S. mansoni worms. When toxic rubber was washed off and ranitidine was used, C. procera (stem latex and flowers) and F. elastica extracts revealed significant S. mansoni worm reductions by 45.31, 53.7 and 16.71%, respectively. Moreover, C. procera extracts produced significant reductions in tissue egg load (similar to 34-38.5%) and positively affected oogram pattern. Conclusion: The present study may be useful to supplement information with regard to C. procera and F. elastica antischistosomal activity and provide a basis for further experimental trials.}},
author = {{el-Din, Sayed H. Seif and El-Lakkany, Naglaa M. and Mohamed, Mona A. and Hamed, Manal M. and Sterner, Olov and Botros, Sanaa S.}},
issn = {{1744-5116}},
keywords = {{Asclepiadaceae; moraceae; oogram pattern; tissue egg load; worm burden; zingiberaceae}},
language = {{eng}},
number = {{2}},
pages = {{144--150}},
publisher = {{Informa Healthcare}},
series = {{Pharmaceutical Biology}},
title = {{Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice}},
url = {{http://dx.doi.org/10.3109/13880209.2013.818041}},
doi = {{10.3109/13880209.2013.818041}},
volume = {{52}},
year = {{2014}},
}