Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study.
(2014) In European Journal of Clinical Nutrition 68. p.453-458- Abstract
- Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an... (More)
- Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.European Journal of Clinical Nutrition advance online publication, 19 February 2014; doi:10.1038/ejcn.2014.12. (Less)
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https://lup.lub.lu.se/record/4334477
- author
- organization
- publishing date
- 2014-02-19
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Nutrition
- volume
- 68
- pages
- 453 - 458
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:24549027
- wos:000333777700008
- scopus:84898006773
- pmid:24549027
- ISSN
- 1476-5640
- DOI
- 10.1038/ejcn.2014.12
- language
- English
- LU publication?
- yes
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- e11f1ce7-0d60-42d6-8d10-9eb36a449d87 (old id 4334477)
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- http://www.ncbi.nlm.nih.gov/pubmed/24549027?dopt=Abstract
- date added to LUP
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@article{e11f1ce7-0d60-42d6-8d10-9eb36a449d87,
abstract = {{Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.European Journal of Clinical Nutrition advance online publication, 19 February 2014; doi:10.1038/ejcn.2014.12.}},
author = {{Magnusdottir, O K and Landberg, R and Gunnarsdottir, I and Cloetens, L and Akesson, B and Landin-Olsson, Mona and Rosqvist, F and Iggman, D and Schwab, U and Herzig, K-H and Savolainen, M J and Brader, L and Hermansen, K and Kolehmainen, M and Poutanen, K and Uusitupa, M and Thorsdottir, I and Risérus, U}},
issn = {{1476-5640}},
language = {{eng}},
month = {{02}},
pages = {{453--458}},
publisher = {{Nature Publishing Group}},
series = {{European Journal of Clinical Nutrition}},
title = {{Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study.}},
url = {{http://dx.doi.org/10.1038/ejcn.2014.12}},
doi = {{10.1038/ejcn.2014.12}},
volume = {{68}},
year = {{2014}},
}