Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.
(2015) In Acta Physiologica 213(1). p.171-180- Abstract
- Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4455749
- author
- Piel, Sarah LU ; Ehinger, Johannes LU ; Elmer, Eskil LU and Hansson, Magnus LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Physiologica
- volume
- 213
- issue
- 1
- pages
- 171 - 180
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:24801139
- wos:000346475000012
- scopus:84940845680
- pmid:24801139
- ISSN
- 1748-1716
- DOI
- 10.1111/apha.12311
- language
- English
- LU publication?
- yes
- id
- c6f1f9fb-b61b-4cf3-b525-b6ab405663a7 (old id 4455749)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24801139?dopt=Abstract
- date added to LUP
- 2016-04-01 10:21:44
- date last changed
- 2024-01-06 14:47:11
@article{c6f1f9fb-b61b-4cf3-b525-b6ab405663a7, abstract = {{Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.}}, author = {{Piel, Sarah and Ehinger, Johannes and Elmer, Eskil and Hansson, Magnus}}, issn = {{1748-1716}}, language = {{eng}}, number = {{1}}, pages = {{171--180}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Physiologica}}, title = {{Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.}}, url = {{http://dx.doi.org/10.1111/apha.12311}}, doi = {{10.1111/apha.12311}}, volume = {{213}}, year = {{2015}}, }