Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
(2014) In BMC Medicine 12(1).- Abstract
- Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4527097
- author
- Hall, Elin LU ; Volkov, Petr LU ; Dayeh, Tasnim LU ; Bacos, Karl LU ; Rönn, Tina LU ; Dekker Nitert, Marloes LU and Ling, Charlotte LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Medicine
- volume
- 12
- issue
- 1
- article number
- 103
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:24953961
- wos:000338252100001
- scopus:84902987423
- pmid:24953961
- ISSN
- 1741-7015
- DOI
- 10.1186/1741-7015-12-103
- language
- English
- LU publication?
- yes
- id
- 0f9ff8c4-1a21-4b97-aaab-1935001d62e6 (old id 4527097)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24953961?dopt=Abstract
- date added to LUP
- 2016-04-01 13:48:16
- date last changed
- 2022-09-20 01:53:53
@article{0f9ff8c4-1a21-4b97-aaab-1935001d62e6, abstract = {{Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.}}, author = {{Hall, Elin and Volkov, Petr and Dayeh, Tasnim and Bacos, Karl and Rönn, Tina and Dekker Nitert, Marloes and Ling, Charlotte}}, issn = {{1741-7015}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Medicine}}, title = {{Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.}}, url = {{https://lup.lub.lu.se/search/files/3599438/5257208}}, doi = {{10.1186/1741-7015-12-103}}, volume = {{12}}, year = {{2014}}, }