Collagenous colitis in systemic sclerosis: an overlooked and treatable complication.
(2014) In Journal of Clinical Rheumatology 20(5). p.278-282- Abstract
- Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the... (More)
- Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the SSc-CC specimen, suggesting a distinct pathogenesis. A literature review revealed 6 previously reported cases of SSc-CC with common clinical features. These observations suggest that CC should be suspected as a rare gastrointestinal complication of SSc and that clinicians should be aware of the possibility in SSc patients developing watery diarrhea. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4581966
- author
- Abignano, Giuseppina ; Scott, Nigel ; Wollheim, Frank LU ; Emery, Paul ; Buch, Maya H and Del Galdo, Francesco
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Rheumatology
- volume
- 20
- issue
- 5
- pages
- 278 - 282
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:25036565
- wos:000340374700008
- scopus:84905123464
- ISSN
- 1536-7355
- DOI
- 10.1097/RHU.0000000000000121
- language
- English
- LU publication?
- yes
- id
- 4be7433f-f898-40b3-97fd-7ab529e95c11 (old id 4581966)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25036565?dopt=Abstract
- date added to LUP
- 2016-04-01 11:00:35
- date last changed
- 2022-03-27 21:38:23
@article{4be7433f-f898-40b3-97fd-7ab529e95c11,
abstract = {{Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the SSc-CC specimen, suggesting a distinct pathogenesis. A literature review revealed 6 previously reported cases of SSc-CC with common clinical features. These observations suggest that CC should be suspected as a rare gastrointestinal complication of SSc and that clinicians should be aware of the possibility in SSc patients developing watery diarrhea.}},
author = {{Abignano, Giuseppina and Scott, Nigel and Wollheim, Frank and Emery, Paul and Buch, Maya H and Del Galdo, Francesco}},
issn = {{1536-7355}},
language = {{eng}},
number = {{5}},
pages = {{278--282}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Clinical Rheumatology}},
title = {{Collagenous colitis in systemic sclerosis: an overlooked and treatable complication.}},
url = {{http://dx.doi.org/10.1097/RHU.0000000000000121}},
doi = {{10.1097/RHU.0000000000000121}},
volume = {{20}},
year = {{2014}},
}