Lung tissue bioengineering for transplantation and modelling of development, disease and regeneration
(2021) In ERS Monograph 2021(91). p.248-272- Abstract
The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current therapies aim to slow disease progression, with lung transplantation remaining the only option at end-stage disease. While a number of discoveries have been made using conventional cell culture and in vivo animal studies, new approaches are needed to develop effective therapies. Recent advances using bioengineering have created new models that... (More)
The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current therapies aim to slow disease progression, with lung transplantation remaining the only option at end-stage disease. While a number of discoveries have been made using conventional cell culture and in vivo animal studies, new approaches are needed to develop effective therapies. Recent advances using bioengineering have created new models that more closely recapitulate human development and disease. In parallel, progress has been made towards generating lung tissue in the laboratory with the ultimate aim of transplantation. This chapter covers the progress and recent advances in applying bioengineering approaches towards improving our understanding of lung development, disease and regeneration.
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- author
- De Santis, Martina M. LU ; Michielin, Federica ; Shibuya, Soichi ; Coppi, Paolo de and Wagner, Darcy E. LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- ERS Monograph
- volume
- 2021
- issue
- 91
- pages
- 248 - 272
- publisher
- European Respiratory Society
- external identifiers
-
- scopus:85143111054
- ISSN
- 2312-508X
- DOI
- 10.1183/2312508X.10011020
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © ERS 2021.
- id
- 461e920e-ce7c-43d5-b8de-1bf3b3513947
- date added to LUP
- 2023-07-16 19:19:37
- date last changed
- 2024-05-16 08:12:14
@article{461e920e-ce7c-43d5-b8de-1bf3b3513947, abstract = {{<p>The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current therapies aim to slow disease progression, with lung transplantation remaining the only option at end-stage disease. While a number of discoveries have been made using conventional cell culture and in vivo animal studies, new approaches are needed to develop effective therapies. Recent advances using bioengineering have created new models that more closely recapitulate human development and disease. In parallel, progress has been made towards generating lung tissue in the laboratory with the ultimate aim of transplantation. This chapter covers the progress and recent advances in applying bioengineering approaches towards improving our understanding of lung development, disease and regeneration.</p>}}, author = {{De Santis, Martina M. and Michielin, Federica and Shibuya, Soichi and Coppi, Paolo de and Wagner, Darcy E.}}, issn = {{2312-508X}}, language = {{eng}}, number = {{91}}, pages = {{248--272}}, publisher = {{European Respiratory Society}}, series = {{ERS Monograph}}, title = {{Lung tissue bioengineering for transplantation and modelling of development, disease and regeneration}}, url = {{http://dx.doi.org/10.1183/2312508X.10011020}}, doi = {{10.1183/2312508X.10011020}}, volume = {{2021}}, year = {{2021}}, }