Tapasin and human leukocyte antigen class I dysregulation correlates with survival in glioblastoma multiforme.
Thuring, Camilla LU ; Geironson Ulfsson, Linda LU and Paulsson, Kajsa M LU
(2014)
In Anti-Cancer Agents in Medicinal Chemistry
14(8).
p.1101-1109
- Abstract
- Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to cytotoxic CD8(+) T cells. Downregulation of peptide:HLA-I complexes is common in tumors and results in tumor immune escape variants. Also molecules involved in the maturation of HLA-I have been demonstrated to be dysregulated in malignant neoplasms. We here set out to investigate the antigen presentation capabilities of a set of 12 glioblastoma multiforme (GBM) tumors based on the expression of HLA-I. Moreover, we analyzed the expression of tapasin, a protein dedicated and essential to HLA-I maturation, as well as the infiltration of CD8+ cells using immunohistochemistry on paraffin-embedded sections. Comparison of different GBMs showed a variation in... (More)
- Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to cytotoxic CD8(+) T cells. Downregulation of peptide:HLA-I complexes is common in tumors and results in tumor immune escape variants. Also molecules involved in the maturation of HLA-I have been demonstrated to be dysregulated in malignant neoplasms. We here set out to investigate the antigen presentation capabilities of a set of 12 glioblastoma multiforme (GBM) tumors based on the expression of HLA-I. Moreover, we analyzed the expression of tapasin, a protein dedicated and essential to HLA-I maturation, as well as the infiltration of CD8+ cells using immunohistochemistry on paraffin-embedded sections. Comparison of different GBMs showed a variation in expression of both HLA-I heavy chain (HC) and tapasin. Interestingly, the expression of tapasin and HLA-I HC correlated significantly (p=0.0002) suggesting tapasin to be a key factor for efficient HLA-I antigen presentation in GBMs. Although no statistically significant correlation between CD8(+) cells and survival was found, probably due to a very low number of infiltrating CD8(+) cells at the time of surgical resection, both tapasin and HLA-I HC levels significantly correlated with survival. We suggest that analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for GBM patients, especially when considering immunotherapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4692792
- author
- Thuring, Camilla
LU
; Geironson Ulfsson, Linda
LU
and Paulsson, Kajsa M
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anti-Cancer Agents in Medicinal Chemistry
- volume
- 14
- issue
- 8
- pages
- 1101 - 1109
- publisher
- Bentham Science Publishers
- external identifiers
-
- pmid:25175688
- wos:000341885400006
- scopus:84907183762
- ISSN
- 1875-5992
- language
- English
- LU publication?
- yes
- id
- e5dd07c2-617d-4349-b402-2a1c9fe1ac03 (old id 4692792)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25175688?dopt=Abstract
- date added to LUP
- 2016-04-01 10:43:00
- date last changed
- 2022-03-27 18:51:46
@article{e5dd07c2-617d-4349-b402-2a1c9fe1ac03,
abstract = {{Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to cytotoxic CD8(+) T cells. Downregulation of peptide:HLA-I complexes is common in tumors and results in tumor immune escape variants. Also molecules involved in the maturation of HLA-I have been demonstrated to be dysregulated in malignant neoplasms. We here set out to investigate the antigen presentation capabilities of a set of 12 glioblastoma multiforme (GBM) tumors based on the expression of HLA-I. Moreover, we analyzed the expression of tapasin, a protein dedicated and essential to HLA-I maturation, as well as the infiltration of CD8+ cells using immunohistochemistry on paraffin-embedded sections. Comparison of different GBMs showed a variation in expression of both HLA-I heavy chain (HC) and tapasin. Interestingly, the expression of tapasin and HLA-I HC correlated significantly (p=0.0002) suggesting tapasin to be a key factor for efficient HLA-I antigen presentation in GBMs. Although no statistically significant correlation between CD8(+) cells and survival was found, probably due to a very low number of infiltrating CD8(+) cells at the time of surgical resection, both tapasin and HLA-I HC levels significantly correlated with survival. We suggest that analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for GBM patients, especially when considering immunotherapy.}},
author = {{Thuring, Camilla and Geironson Ulfsson, Linda and Paulsson, Kajsa M}},
issn = {{1875-5992}},
language = {{eng}},
number = {{8}},
pages = {{1101--1109}},
publisher = {{Bentham Science Publishers}},
series = {{Anti-Cancer Agents in Medicinal Chemistry}},
title = {{Tapasin and human leukocyte antigen class I dysregulation correlates with survival in glioblastoma multiforme.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/25175688?dopt=Abstract}},
volume = {{14}},
year = {{2014}},
}