Imaging Dynamics Beneath Turbid Media via Parallelized Single-Photon Detection
Xu, Shiqi ; Yang, Xi ; Liu, Wenhui ; Jönsson, Joakim LU
; Qian, Ruobing
; Konda, Pavan Chandra
; Zhou, Kevin C.
; Kreiß, Lucas
; Wang, Haoqian
and Dai, Qionghai
, et al.
(2022)
In Advanced Science
9(24).
- Abstract
Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep-tissue video reconstruction of decorrelation dynamics. In this work, a single-photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single-photon level from 12 different... (More)
Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep-tissue video reconstruction of decorrelation dynamics. In this work, a single-photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single-photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. Then a deep neural network is applied to convert the acquired single-photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. The ability to reconstruct images of transient (0.1–0.4 s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter-scale resolution is demonstrated, and it is highlighted how the model can flexibly extend to monitor flow speed within buried phantom vessels.
(Less)
- author
- Xu, Shiqi
; Yang, Xi
; Liu, Wenhui
; Jönsson, Joakim
LU
; Qian, Ruobing
; Konda, Pavan Chandra
; Zhou, Kevin C.
; Kreiß, Lucas
; Wang, Haoqian
and Dai, Qionghai
, et al. (More)
- Xu, Shiqi
; Yang, Xi
; Liu, Wenhui
; Jönsson, Joakim
LU
; Qian, Ruobing
; Konda, Pavan Chandra
; Zhou, Kevin C.
; Kreiß, Lucas
; Wang, Haoqian
; Dai, Qionghai
; Berrocal, Edouard
LU
and Horstmeyer, Roarke
(Less)
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- deep imaging, dynamic scattering, single-photon avalanche diode array
- in
- Advanced Science
- volume
- 9
- issue
- 24
- article number
- 2201885
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85132586925
- pmid:35748188
- ISSN
- 2198-3844
- DOI
- 10.1002/advs.202201885
- language
- English
- LU publication?
- yes
- id
- 4753a798-f6fc-42b9-97aa-6cb5a21c1044
- date added to LUP
- 2022-10-06 15:07:44
- date last changed
- 2024-08-09 00:50:35
@article{4753a798-f6fc-42b9-97aa-6cb5a21c1044,
abstract = {{<p>Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep-tissue video reconstruction of decorrelation dynamics. In this work, a single-photon avalanche diode array camera is utilized to simultaneously monitor the temporal dynamics of speckle fluctuations at the single-photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. Then a deep neural network is applied to convert the acquired single-photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. The ability to reconstruct images of transient (0.1–0.4 s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter-scale resolution is demonstrated, and it is highlighted how the model can flexibly extend to monitor flow speed within buried phantom vessels.</p>}},
author = {{Xu, Shiqi and Yang, Xi and Liu, Wenhui and Jönsson, Joakim and Qian, Ruobing and Konda, Pavan Chandra and Zhou, Kevin C. and Kreiß, Lucas and Wang, Haoqian and Dai, Qionghai and Berrocal, Edouard and Horstmeyer, Roarke}},
issn = {{2198-3844}},
keywords = {{deep imaging; dynamic scattering; single-photon avalanche diode array}},
language = {{eng}},
number = {{24}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Advanced Science}},
title = {{Imaging Dynamics Beneath Turbid Media via Parallelized Single-Photon Detection}},
url = {{http://dx.doi.org/10.1002/advs.202201885}},
doi = {{10.1002/advs.202201885}},
volume = {{9}},
year = {{2022}},
}