The influence of methylphenidate on auditory brainstem response patients with attention deficit hyperactivity disorder; an exploratory study
(2023) In Journal of Public Health Research 12(4).- Abstract
- Background:
Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with... (More) - Background:
Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with ADHD.
Methods:
We recruited 32 drug-naïve children and adolescents (19 males and 13 females; mean age 11 years) diagnosed with ADHD and 35 health controls (15 males and 20 females; mean age 12 years). The ADHD group was treated with Methylphenidate, and ABR was recorded before treatment and at a steady state of medical treatment.
Results:
Medicated ADHD patients exhibited increased activity in the right side ABR in Wave VI.
Conclusions:
A significant increase in activity was found in a part of the ABR thought to correspond to the thalamic area in medicated ADHD patients compared to the same area of non-medicated ADHD patients. The results add to the growing body of research suggesting that specific ABR peaks correlate to certain psychiatric symptoms. (Less)
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https://lup.lub.lu.se/record/480ecb65-2f60-426b-b57e-cbda63bc4795
- author
- Claesdotter-Knutsson, Emma LU ; Källstrand, Johan ; Niklasson, Katalin LU ; Andersson, Mitchell LU and Lindvall, Magnus LU
- organization
-
- Lund Clinical Research on Externalizing and Developmental psychopathology (LU-CRED) (research group)
- LUNDD (LUnd Neurodevelopmental Disorders) (research group)
- Child and Adolescent Psychiatry
- Clinical addiction research unit (research group)
- Psychiatry (Lund)
- Brain function and behavioral mechanisms in psychopathology (research group)
- publishing date
- 2023-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Public Health Research
- volume
- 12
- issue
- 4
- publisher
- Page Press
- external identifiers
-
- scopus:85175695054
- ISSN
- 2279-9028
- DOI
- 10.1177/22799036231204
- language
- English
- LU publication?
- yes
- id
- 480ecb65-2f60-426b-b57e-cbda63bc4795
- date added to LUP
- 2023-10-25 11:58:58
- date last changed
- 2023-11-23 15:11:14
@article{480ecb65-2f60-426b-b57e-cbda63bc4795, abstract = {{Background:<br/>Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with ADHD.<br/>Methods:<br/>We recruited 32 drug-naïve children and adolescents (19 males and 13 females; mean age 11 years) diagnosed with ADHD and 35 health controls (15 males and 20 females; mean age 12 years). The ADHD group was treated with Methylphenidate, and ABR was recorded before treatment and at a steady state of medical treatment.<br/>Results:<br/>Medicated ADHD patients exhibited increased activity in the right side ABR in Wave VI.<br/>Conclusions:<br/>A significant increase in activity was found in a part of the ABR thought to correspond to the thalamic area in medicated ADHD patients compared to the same area of non-medicated ADHD patients. The results add to the growing body of research suggesting that specific ABR peaks correlate to certain psychiatric symptoms.}}, author = {{Claesdotter-Knutsson, Emma and Källstrand, Johan and Niklasson, Katalin and Andersson, Mitchell and Lindvall, Magnus}}, issn = {{2279-9028}}, language = {{eng}}, number = {{4}}, publisher = {{Page Press}}, series = {{Journal of Public Health Research}}, title = {{The influence of methylphenidate on auditory brainstem response patients with attention deficit hyperactivity disorder; an exploratory study}}, url = {{http://dx.doi.org/10.1177/22799036231204}}, doi = {{10.1177/22799036231204}}, volume = {{12}}, year = {{2023}}, }