Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.
Esguerra, Jonathan LU
; Mollet, Ines
LU
; Salunkhe, Vishal Ashok
LU
; Wendt, Anna
LU
and Eliasson, Lena
LU
(2014)
In Genes
5(4).
p.1018-1031
- Abstract
- Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of... (More)
- Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of post-transcriptional regulation, microRNAs (miRNAs) are well-recognized mediators of beta cell plasticity and adaptation. Here, we put focus on the importance of comprehending the transcriptional regulation of miRNAs, and how miRNAs are implicated in stimulus-secretion coupling, specifically those influencing the late stages of insulin secretion. We suggest that efficient beta cell adaptation requires an optimal balance between transcriptional regulation of miRNAs themselves, and miRNA-dependent gene regulation. The increased knowledge of the beta cell transcriptional network inclusive of non-coding RNAs such as miRNAs is essential in identifying novel targets for the treatment of T2D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4817068
- author
- Esguerra, Jonathan
LU
; Mollet, Ines
LU
; Salunkhe, Vishal Ashok
LU
; Wendt, Anna
LU
and Eliasson, Lena
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes
- volume
- 5
- issue
- 4
- pages
- 1018 - 1031
- publisher
- MDPI AG
- external identifiers
-
- pmid:25383562
- wos:000348858000007
- scopus:84908672563
- pmid:25383562
- ISSN
- 2073-4425
- DOI
- 10.3390/genes5041018
- language
- English
- LU publication?
- yes
- id
- aa0c27ed-24f0-4a4c-a3fa-7ee0f2c3c84b (old id 4817068)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25383562?dopt=Abstract
- date added to LUP
- 2016-04-01 12:50:23
- date last changed
- 2022-01-27 07:55:59
@article{aa0c27ed-24f0-4a4c-a3fa-7ee0f2c3c84b,
abstract = {{Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of post-transcriptional regulation, microRNAs (miRNAs) are well-recognized mediators of beta cell plasticity and adaptation. Here, we put focus on the importance of comprehending the transcriptional regulation of miRNAs, and how miRNAs are implicated in stimulus-secretion coupling, specifically those influencing the late stages of insulin secretion. We suggest that efficient beta cell adaptation requires an optimal balance between transcriptional regulation of miRNAs themselves, and miRNA-dependent gene regulation. The increased knowledge of the beta cell transcriptional network inclusive of non-coding RNAs such as miRNAs is essential in identifying novel targets for the treatment of T2D.}},
author = {{Esguerra, Jonathan and Mollet, Ines and Salunkhe, Vishal Ashok and Wendt, Anna and Eliasson, Lena}},
issn = {{2073-4425}},
language = {{eng}},
number = {{4}},
pages = {{1018--1031}},
publisher = {{MDPI AG}},
series = {{Genes}},
title = {{Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.}},
url = {{https://lup.lub.lu.se/search/files/3008517/5462427.pdf}},
doi = {{10.3390/genes5041018}},
volume = {{5}},
year = {{2014}},
}