Local treatments for metastases of renal cell carcinoma: a systematic review
(2014) In The Lancet Oncology 15(12). p.549-561- Abstract
- Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across... (More)
- Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4865350
- author
- Dabestani, Saeed LU ; Marconi, Lorenzo ; Hofmann, Fabian ; Stewart, Fiona ; Lam, Thomas B. L. ; Canfield, Steven E. ; Staehler, Michael ; Powles, Thomas ; Ljungberg, Boerje and Bex, Axel
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet Oncology
- volume
- 15
- issue
- 12
- pages
- 549 - 561
- publisher
- Elsevier
- external identifiers
-
- wos:000344546400023
- pmid:25439697
- scopus:84908590983
- ISSN
- 1474-5488
- DOI
- 10.1016/S1470-2045(14)70235-9
- language
- English
- LU publication?
- yes
- id
- 4a5d5e59-fc00-42ef-8e44-3726b7c04bd9 (old id 4865350)
- date added to LUP
- 2016-04-01 10:31:10
- date last changed
- 2022-04-27 22:36:20
@article{4a5d5e59-fc00-42ef-8e44-3726b7c04bd9,
abstract = {{Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research.}},
author = {{Dabestani, Saeed and Marconi, Lorenzo and Hofmann, Fabian and Stewart, Fiona and Lam, Thomas B. L. and Canfield, Steven E. and Staehler, Michael and Powles, Thomas and Ljungberg, Boerje and Bex, Axel}},
issn = {{1474-5488}},
language = {{eng}},
number = {{12}},
pages = {{549--561}},
publisher = {{Elsevier}},
series = {{The Lancet Oncology}},
title = {{Local treatments for metastases of renal cell carcinoma: a systematic review}},
url = {{http://dx.doi.org/10.1016/S1470-2045(14)70235-9}},
doi = {{10.1016/S1470-2045(14)70235-9}},
volume = {{15}},
year = {{2014}},
}