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New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction

Swärd, Karl LU ; Albinsson, Sebastian LU and Rippe, Catarina LU (2021) In Cardiac and Vascular Biology 8. p.69-96
Abstract

YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses how YAP and TAZ are activated by mechanical cues, their potential arterial target genes, and plausible roles of YAP/TAZ in arterial health and disease. It is concluded that local and specific strategies are needed for YAP/TAZ targeting in cardiovascular disease treatment.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Angiogenesis, Aortic aneurysm, Arterial remodeling, Atherosclerosis, Phenotypic modulation, Shear, WWTR1, YAP1
host publication
Vascular Mechanobiology in Physiology and Disease
series title
Cardiac and Vascular Biology
volume
8
pages
28 pages
publisher
Springer Science and Business Media B.V.
external identifiers
  • scopus:85102485344
ISSN
2509-7830
2509-7849
ISBN
978-3-030-63164-2
DOI
10.1007/978-3-030-63164-2_4
language
English
LU publication?
yes
id
490284d5-d1e7-43c1-b888-fc87b54696ac
date added to LUP
2021-03-29 08:11:56
date last changed
2024-09-21 17:51:10
@inbook{490284d5-d1e7-43c1-b888-fc87b54696ac,
  abstract     = {{<p>YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses how YAP and TAZ are activated by mechanical cues, their potential arterial target genes, and plausible roles of YAP/TAZ in arterial health and disease. It is concluded that local and specific strategies are needed for YAP/TAZ targeting in cardiovascular disease treatment.</p>}},
  author       = {{Swärd, Karl and Albinsson, Sebastian and Rippe, Catarina}},
  booktitle    = {{Vascular Mechanobiology in Physiology and Disease}},
  isbn         = {{978-3-030-63164-2}},
  issn         = {{2509-7830}},
  keywords     = {{Angiogenesis; Aortic aneurysm; Arterial remodeling; Atherosclerosis; Phenotypic modulation; Shear; WWTR1; YAP1}},
  language     = {{eng}},
  pages        = {{69--96}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{Cardiac and Vascular Biology}},
  title        = {{New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction}},
  url          = {{http://dx.doi.org/10.1007/978-3-030-63164-2_4}},
  doi          = {{10.1007/978-3-030-63164-2_4}},
  volume       = {{8}},
  year         = {{2021}},
}