New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction
(2021) In Cardiac and Vascular Biology 8. p.69-96- Abstract
YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses how YAP and TAZ are activated by mechanical cues, their potential arterial target genes, and plausible roles of YAP/TAZ in arterial health and disease. It is concluded that local and specific strategies are needed for YAP/TAZ targeting in cardiovascular disease treatment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/490284d5-d1e7-43c1-b888-fc87b54696ac
- author
- Swärd, Karl LU ; Albinsson, Sebastian LU and Rippe, Catarina LU
- organization
- publishing date
- 2021
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Angiogenesis, Aortic aneurysm, Arterial remodeling, Atherosclerosis, Phenotypic modulation, Shear, WWTR1, YAP1
- host publication
- Vascular Mechanobiology in Physiology and Disease
- series title
- Cardiac and Vascular Biology
- volume
- 8
- pages
- 28 pages
- publisher
- Springer Science and Business Media B.V.
- external identifiers
-
- scopus:85102485344
- ISSN
- 2509-7830
- 2509-7849
- ISBN
- 978-3-030-63164-2
- DOI
- 10.1007/978-3-030-63164-2_4
- language
- English
- LU publication?
- yes
- id
- 490284d5-d1e7-43c1-b888-fc87b54696ac
- date added to LUP
- 2021-03-29 08:11:56
- date last changed
- 2024-09-21 17:51:10
@inbook{490284d5-d1e7-43c1-b888-fc87b54696ac, abstract = {{<p>YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses how YAP and TAZ are activated by mechanical cues, their potential arterial target genes, and plausible roles of YAP/TAZ in arterial health and disease. It is concluded that local and specific strategies are needed for YAP/TAZ targeting in cardiovascular disease treatment.</p>}}, author = {{Swärd, Karl and Albinsson, Sebastian and Rippe, Catarina}}, booktitle = {{Vascular Mechanobiology in Physiology and Disease}}, isbn = {{978-3-030-63164-2}}, issn = {{2509-7830}}, keywords = {{Angiogenesis; Aortic aneurysm; Arterial remodeling; Atherosclerosis; Phenotypic modulation; Shear; WWTR1; YAP1}}, language = {{eng}}, pages = {{69--96}}, publisher = {{Springer Science and Business Media B.V.}}, series = {{Cardiac and Vascular Biology}}, title = {{New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction}}, url = {{http://dx.doi.org/10.1007/978-3-030-63164-2_4}}, doi = {{10.1007/978-3-030-63164-2_4}}, volume = {{8}}, year = {{2021}}, }