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Lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets

Nord, Anders LU ; Cunha-Goncalves, Doris LU ; Linnér, Rikard LU ; Bianco, Federico ; Salomone, Fabrizio ; Ricci, Francesca ; Lombardini, Marta ; Micaglio, Massimo ; Trevisanuto, Daniele and Perez-De-sa, Valeria LU (2021) In Pharmaceutics 13(11).
Abstract

It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100... (More)

It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg−1 of poractant alfa mixed with99mTechnetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Laryngeal mask airway, Lung deposition, Newborn, Scintigraphy, Surfactant
in
Pharmaceutics
volume
13
issue
11
article number
1858
publisher
MDPI AG
external identifiers
  • pmid:34834273
  • scopus:85118760054
ISSN
1999-4923
DOI
10.3390/pharmaceutics13111858
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
id
494376d4-50fd-4d6d-95f1-92b37a1e12f3
date added to LUP
2021-12-03 14:34:14
date last changed
2024-09-08 06:09:52
@article{494376d4-50fd-4d6d-95f1-92b37a1e12f3,
  abstract     = {{<p>It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg<sup>−1</sup> of poractant alfa mixed with<sup>99m</sup>Technetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p &lt; 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.</p>}},
  author       = {{Nord, Anders and Cunha-Goncalves, Doris and Linnér, Rikard and Bianco, Federico and Salomone, Fabrizio and Ricci, Francesca and Lombardini, Marta and Micaglio, Massimo and Trevisanuto, Daniele and Perez-De-sa, Valeria}},
  issn         = {{1999-4923}},
  keywords     = {{Laryngeal mask airway; Lung deposition; Newborn; Scintigraphy; Surfactant}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Pharmaceutics}},
  title        = {{Lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets}},
  url          = {{http://dx.doi.org/10.3390/pharmaceutics13111858}},
  doi          = {{10.3390/pharmaceutics13111858}},
  volume       = {{13}},
  year         = {{2021}},
}