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Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

Aaltonen, H. Laura LU ; Petersson Sjögren, Madeleine LU ; Jakobsson, Jonas K.F. LU ; Nicklasson, Hanna LU ; Diaz, Sandra LU ; Sánchez Montiel, Francisco ; Zackrisson, Sophia LU ; Ideböhn, Veronica LU ; Engström, Gunnar LU and Löndahl, Jakob LU orcid , et al. (2021) In Thorax 76(10). p.1040-1043
Abstract

Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291... (More)

Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
emphysema, exhaled airway markers, imaging/CT MRI, respiratory measurement
in
Thorax
volume
76
issue
10
pages
1040 - 1043
publisher
BMJ Publishing Group
external identifiers
  • scopus:85104459368
  • pmid:33859054
ISSN
0040-6376
DOI
10.1136/thoraxjnl-2020-214523
language
English
LU publication?
yes
id
4b77a3b3-da95-42c1-897a-462fa2b446c0
date added to LUP
2021-05-03 18:22:44
date last changed
2025-01-26 10:00:24
@article{4b77a3b3-da95-42c1-897a-462fa2b446c0,
  abstract     = {{<p>Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p&lt;0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p&lt;0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.</p>}},
  author       = {{Aaltonen, H. Laura and Petersson Sjögren, Madeleine and Jakobsson, Jonas K.F. and Nicklasson, Hanna and Diaz, Sandra and Sánchez Montiel, Francisco and Zackrisson, Sophia and Ideböhn, Veronica and Engström, Gunnar and Löndahl, Jakob and Wollmer, Per}},
  issn         = {{0040-6376}},
  keywords     = {{emphysema; exhaled airway markers; imaging/CT MRI; respiratory measurement}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1040--1043}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Thorax}},
  title        = {{Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema}},
  url          = {{http://dx.doi.org/10.1136/thoraxjnl-2020-214523}},
  doi          = {{10.1136/thoraxjnl-2020-214523}},
  volume       = {{76}},
  year         = {{2021}},
}