Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting
Poveda, Alaitz LU
; Chen, Yan
LU
; Pomares-Millan, Hugo
LU
; Kurbasic, Azra
LU
; Patel, Chirag J.
LU
; Renström, Frida
LU
; Hallmans, Göran
; Johansson, Ingegerd
and Franks, Paul W.
LU
(2021)
p.1-4
- Abstract
- The present study aims to assess the over-time association of ∼300 lifestyle exposures with nine cardiometabolic traits with the ultimate aim of identifying exposures/exposure groups that could inform lifestyle interventions aiming at controlling cardiometabolic diseases. The analyses were undertaken in a longitudinal sample comprising >31000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test association with 10-year change of the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association... (More)
- The present study aims to assess the over-time association of ∼300 lifestyle exposures with nine cardiometabolic traits with the ultimate aim of identifying exposures/exposure groups that could inform lifestyle interventions aiming at controlling cardiometabolic diseases. The analyses were undertaken in a longitudinal sample comprising >31000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test association with 10-year change of the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top-category for the 10-year change association analyses. Thirteen modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to four main groups: i) Smoking, ii) Diet (secoisolariciresinol intake and brewed coffee), iii) Leisure time physical activity and iv) a group of variables more specific to the Swedish lifestyle (snuff status, hunting/fishing during leisure time and boiled coffee). Interestingly, sweet drinks, fish intake and salt content, all lifestyle exposures frequently mentioned in public health recommendations were not broadly associated with the analysed cardiometabolic traits. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4daeb827-affc-4114-8fad-4ea39419bdad
- author
- Poveda, Alaitz
LU
; Chen, Yan
LU
; Pomares-Millan, Hugo
LU
; Kurbasic, Azra
LU
; Patel, Chirag J.
LU
; Renström, Frida
LU
; Hallmans, Göran
; Johansson, Ingegerd
and Franks, Paul W.
LU
- organization
- publishing date
- 2021
- type
- Working paper/Preprint
- publication status
- published
- subject
- pages
- 1 - 4
- publisher
- medRxiv
- DOI
- 10.1101/2021.03.22.21254099
- language
- English
- LU publication?
- yes
- id
- 4daeb827-affc-4114-8fad-4ea39419bdad
- date added to LUP
- 2022-01-26 18:24:16
- date last changed
- 2022-06-29 13:59:19
@misc{4daeb827-affc-4114-8fad-4ea39419bdad,
abstract = {{The present study aims to assess the over-time association of ∼300 lifestyle exposures with nine cardiometabolic traits with the ultimate aim of identifying exposures/exposure groups that could inform lifestyle interventions aiming at controlling cardiometabolic diseases. The analyses were undertaken in a longitudinal sample comprising >31000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test association with 10-year change of the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top-category for the 10-year change association analyses. Thirteen modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to four main groups: i) Smoking, ii) Diet (secoisolariciresinol intake and brewed coffee), iii) Leisure time physical activity and iv) a group of variables more specific to the Swedish lifestyle (snuff status, hunting/fishing during leisure time and boiled coffee). Interestingly, sweet drinks, fish intake and salt content, all lifestyle exposures frequently mentioned in public health recommendations were not broadly associated with the analysed cardiometabolic traits.}},
author = {{Poveda, Alaitz and Chen, Yan and Pomares-Millan, Hugo and Kurbasic, Azra and Patel, Chirag J. and Renström, Frida and Hallmans, Göran and Johansson, Ingegerd and Franks, Paul W.}},
language = {{eng}},
note = {{Preprint}},
pages = {{1--4}},
publisher = {{medRxiv}},
title = {{Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting}},
url = {{http://dx.doi.org/10.1101/2021.03.22.21254099}},
doi = {{10.1101/2021.03.22.21254099}},
year = {{2021}},
}