Monotherapy with infusion therapies – useful or not?
Rožanković, Petra Bago ; Johansson, Anders ; Péter, Klivényi ; Milanov, Ivan and Odin, Per LU
(2024)
In Journal of Neural Transmission
131(11).
p.1341-1348
- Abstract
Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with infusion-based therapies could simplify the treatment regimen, provide better medication adherence, reduce adverse events and drug interactions. This review presents the literature data on the efficacy, safety, and achievability of monotherapy with all available infusion-based therapies, including apomorphine, levodopa-carbidopa-intestinal gel (LCIG), levodopa-entacapone-carbidopa intestinal gel (LECIG), and foslevodopa-foscarbidopa (LDp/CDp). In summary, monotherapy is achievable and effective in most patients on intestinal levodopa infusion therapy and in some patients on apomorphine infusion.... (More)
Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with infusion-based therapies could simplify the treatment regimen, provide better medication adherence, reduce adverse events and drug interactions. This review presents the literature data on the efficacy, safety, and achievability of monotherapy with all available infusion-based therapies, including apomorphine, levodopa-carbidopa-intestinal gel (LCIG), levodopa-entacapone-carbidopa intestinal gel (LECIG), and foslevodopa-foscarbidopa (LDp/CDp). In summary, monotherapy is achievable and effective in most patients on intestinal levodopa infusion therapy and in some patients on apomorphine infusion. There is a need for further investigation of monotherapy compared to polytherapy, especially in new pump treatment options (LECIG and LDp/CDp). Future research should reveal which patients on infusion-based therapies could benefit from monotherapy, including identification of potential baseline predictors of achieving monotherapy in patients treated with specific infusion-based therapies.
(Less)
- author
- Rožanković, Petra Bago
; Johansson, Anders
; Péter, Klivényi
; Milanov, Ivan
and Odin, Per
LU
- organization
- publishing date
- 2024-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Advanced parkinson´s disease, Infusion therapies, Monotherapy
- in
- Journal of Neural Transmission
- volume
- 131
- issue
- 11
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- scopus:85197665629
- pmid:38967810
- ISSN
- 0300-9564
- DOI
- 10.1007/s00702-024-02801-2
- language
- English
- LU publication?
- yes
- id
- 50463d6b-d22d-4a52-be91-270d01e10afa
- date added to LUP
- 2024-12-12 11:45:48
- date last changed
- 2025-07-11 04:53:29
@article{50463d6b-d22d-4a52-be91-270d01e10afa,
abstract = {{<p>Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with infusion-based therapies could simplify the treatment regimen, provide better medication adherence, reduce adverse events and drug interactions. This review presents the literature data on the efficacy, safety, and achievability of monotherapy with all available infusion-based therapies, including apomorphine, levodopa-carbidopa-intestinal gel (LCIG), levodopa-entacapone-carbidopa intestinal gel (LECIG), and foslevodopa-foscarbidopa (LDp/CDp). In summary, monotherapy is achievable and effective in most patients on intestinal levodopa infusion therapy and in some patients on apomorphine infusion. There is a need for further investigation of monotherapy compared to polytherapy, especially in new pump treatment options (LECIG and LDp/CDp). Future research should reveal which patients on infusion-based therapies could benefit from monotherapy, including identification of potential baseline predictors of achieving monotherapy in patients treated with specific infusion-based therapies.</p>}},
author = {{Rožanković, Petra Bago and Johansson, Anders and Péter, Klivényi and Milanov, Ivan and Odin, Per}},
issn = {{0300-9564}},
keywords = {{Advanced parkinson´s disease; Infusion therapies; Monotherapy}},
language = {{eng}},
number = {{11}},
pages = {{1341--1348}},
publisher = {{Springer}},
series = {{Journal of Neural Transmission}},
title = {{Monotherapy with infusion therapies – useful or not?}},
url = {{http://dx.doi.org/10.1007/s00702-024-02801-2}},
doi = {{10.1007/s00702-024-02801-2}},
volume = {{131}},
year = {{2024}},
}