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Effects of neuromuscular electrical stimulation on energy expenditure and postprandial metabolism in healthy men

Chen, Yung Chih ; Davies, Russell G. ; Hengist, Aaron ; Carroll, Harriet A. LU orcid ; Perkin, Oliver J. ; Betts, James A. and Thompson, Dylan (2022) In Applied Physiology, Nutrition and Metabolism 47(1). p.27-33
Abstract

It is unclear whether neuromuscular electrical stimulation (NMES) has meaningful metabolic effects when users have the opportunity to self-select the intensity to one that can be comfortably tolerated. Nine healthy men aged 28 6 9y (mean 6 SD) with a body mass index 22.3 6 2.3 kg/m2 completed 3 trials involving a 2-h oral glucose tolerance test whilst, in a randomised counterbalanced order, (1) sitting motionless (SIT), (2) standing motionless (STAND); and (3) sitting motionless with NMES of quadriceps and calves at a self-selected tolerable intensity. The mean (95% confidence interval [CI]) total energy expenditure was greater in the NMES trial (221 [180–262] kcal/2 h) and STAND trial (178 [164–191] kcal/2 h) than during SIT... (More)

It is unclear whether neuromuscular electrical stimulation (NMES) has meaningful metabolic effects when users have the opportunity to self-select the intensity to one that can be comfortably tolerated. Nine healthy men aged 28 6 9y (mean 6 SD) with a body mass index 22.3 6 2.3 kg/m2 completed 3 trials involving a 2-h oral glucose tolerance test whilst, in a randomised counterbalanced order, (1) sitting motionless (SIT), (2) standing motionless (STAND); and (3) sitting motionless with NMES of quadriceps and calves at a self-selected tolerable intensity. The mean (95% confidence interval [CI]) total energy expenditure was greater in the NMES trial (221 [180–262] kcal/2 h) and STAND trial (178 [164–191] kcal/2 h) than during SIT (159 [150–167] kcal/2 h) (both, p < 0.05). This was primarily driven by an increase in carbohydrate oxidation in the NMES and STAND trials compared with the SIT trial (p < 0.05). Postprandial insulin iAUC was lower in both NMES and STAND compared with SIT (16.4 [7.7–25.1], 17 [7–27] and 22.6 [10.8–34.4] nmol·120 min/L, respectively; both, p < 0.05). Compared with sitting, both NMES and STAND increased energy expenditure and whole-body carbohydrate oxidation and reduced postprandial insulin concentrations in healthy men, with more pronounced effects seen with NMES. Self-selected NMES is a potential strategy for improving metabolic health. This trial is registered at ClinicalTrials.gov (ID: NCT04389736). Novelty: • NMES at a comfortable intensity enhances energy expenditure and carbohydrate oxidation, and reduces postprandial insulinemia. • Thus, self-selected NMES represents a potential strategy to improve metabolic health.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Carbohydrate oxidation, Glucose control, Insulin resistance, NMES, Standing
in
Applied Physiology, Nutrition and Metabolism
volume
47
issue
1
pages
7 pages
publisher
National Research Council Canada
external identifiers
  • scopus:85122481565
  • pmid:34403626
ISSN
1715-5312
DOI
10.1139/apnm-2021-0361
language
English
LU publication?
yes
id
50fdfab3-3b4f-4568-a6f8-daef2de4a02d
date added to LUP
2022-03-01 10:04:24
date last changed
2024-06-27 12:34:32
@article{50fdfab3-3b4f-4568-a6f8-daef2de4a02d,
  abstract     = {{<p>It is unclear whether neuromuscular electrical stimulation (NMES) has meaningful metabolic effects when users have the opportunity to self-select the intensity to one that can be comfortably tolerated. Nine healthy men aged 28 6 9y (mean 6 SD) with a body mass index 22.3 6 2.3 kg/m<sup>2</sup> completed 3 trials involving a 2-h oral glucose tolerance test whilst, in a randomised counterbalanced order, (1) sitting motionless (SIT), (2) standing motionless (STAND); and (3) sitting motionless with NMES of quadriceps and calves at a self-selected tolerable intensity. The mean (95% confidence interval [CI]) total energy expenditure was greater in the NMES trial (221 [180–262] kcal/2 h) and STAND trial (178 [164–191] kcal/2 h) than during SIT (159 [150–167] kcal/2 h) (both, p &lt; 0.05). This was primarily driven by an increase in carbohydrate oxidation in the NMES and STAND trials compared with the SIT trial (p &lt; 0.05). Postprandial insulin iAUC was lower in both NMES and STAND compared with SIT (16.4 [7.7–25.1], 17 [7–27] and 22.6 [10.8–34.4] nmol·120 min/L, respectively; both, p &lt; 0.05). Compared with sitting, both NMES and STAND increased energy expenditure and whole-body carbohydrate oxidation and reduced postprandial insulin concentrations in healthy men, with more pronounced effects seen with NMES. Self-selected NMES is a potential strategy for improving metabolic health. This trial is registered at ClinicalTrials.gov (ID: NCT04389736). Novelty: • NMES at a comfortable intensity enhances energy expenditure and carbohydrate oxidation, and reduces postprandial insulinemia. • Thus, self-selected NMES represents a potential strategy to improve metabolic health.</p>}},
  author       = {{Chen, Yung Chih and Davies, Russell G. and Hengist, Aaron and Carroll, Harriet A. and Perkin, Oliver J. and Betts, James A. and Thompson, Dylan}},
  issn         = {{1715-5312}},
  keywords     = {{Carbohydrate oxidation; Glucose control; Insulin resistance; NMES; Standing}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{27--33}},
  publisher    = {{National Research Council Canada}},
  series       = {{Applied Physiology, Nutrition and Metabolism}},
  title        = {{Effects of neuromuscular electrical stimulation on energy expenditure and postprandial metabolism in healthy men}},
  url          = {{http://dx.doi.org/10.1139/apnm-2021-0361}},
  doi          = {{10.1139/apnm-2021-0361}},
  volume       = {{47}},
  year         = {{2022}},
}