Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema : Proof of concept for a novel diagnostic technique
(2018) In Clinical Physiology and Functional Imaging 38(6). p.1008-1014- Abstract
Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. Method: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation... (More)
Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. Method: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation followed by breath-hold. Particle concentrations in the inhaled aerosol, and in an alveolar sample exhaled after breath-hold, were measured to obtain recovery. Findings: The patients with COPD had a significantly higher mean recovery than controls, 0·128 ± 0·063 versus 0·074 ± 0·058; P = 0·010. Also, recovery correlated significantly with computed tomography (CT) densitometry variables (P<0·01) and diffusing capacity for carbon monoxide (DL,CO; P = 0·002). Interpretation: Higher recovery for emphysema patients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.
(Less)
- author
- Aaltonen, H. L. LU ; Jakobsson, J. K. LU ; Diaz, S. LU ; Zackrisson, S. LU ; Piitulainen, E. LU ; Löndahl, J. LU and Wollmer, P. LU
- organization
- publishing date
- 2018-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AiDA, COPD, CT densitometry, Emphysema, Nanoparticles, Respiratory diagnostics
- in
- Clinical Physiology and Functional Imaging
- volume
- 38
- issue
- 6
- pages
- 1008 - 1014
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:29635884
- scopus:85045201899
- ISSN
- 1475-0961
- DOI
- 10.1111/cpf.12517
- language
- English
- LU publication?
- yes
- id
- 57e5aa7a-5912-41bb-b090-3115e717dd58
- date added to LUP
- 2018-04-23 11:05:43
- date last changed
- 2024-07-08 13:01:25
@article{57e5aa7a-5912-41bb-b090-3115e717dd58, abstract = {{<p>Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. Method: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation followed by breath-hold. Particle concentrations in the inhaled aerosol, and in an alveolar sample exhaled after breath-hold, were measured to obtain recovery. Findings: The patients with COPD had a significantly higher mean recovery than controls, 0·128 ± 0·063 versus 0·074 ± 0·058; P = 0·010. Also, recovery correlated significantly with computed tomography (CT) densitometry variables (P<0·01) and diffusing capacity for carbon monoxide (D<sub>L,CO</sub>; P = 0·002). Interpretation: Higher recovery for emphysema patients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.</p>}}, author = {{Aaltonen, H. L. and Jakobsson, J. K. and Diaz, S. and Zackrisson, S. and Piitulainen, E. and Löndahl, J. and Wollmer, P.}}, issn = {{1475-0961}}, keywords = {{AiDA; COPD; CT densitometry; Emphysema; Nanoparticles; Respiratory diagnostics}}, language = {{eng}}, number = {{6}}, pages = {{1008--1014}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Clinical Physiology and Functional Imaging}}, title = {{Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema : Proof of concept for a novel diagnostic technique}}, url = {{http://dx.doi.org/10.1111/cpf.12517}}, doi = {{10.1111/cpf.12517}}, volume = {{38}}, year = {{2018}}, }