Amino acids predict prognosis in patients with acute dyspnea
(2021) In BMC Emergency Medicine 21(1).- Abstract
Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of... (More)
Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was > 9 times higher in Q4. Conclusion: Glycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.
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- author
- Wiklund, Karolin LU ; Gränsbo, Klas LU ; Almgren, Peter LU ; Peyman, Marjaneh LU ; Tegnér, Lena LU ; Toni-Bengtsson, Maria ; Wieloch, Mattias LU and Melander, Olle LU
- organization
- publishing date
- 2021-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amino acids, Dyspnea, Emergency service, hospital, Glycine, Phenylalanine, Valine
- in
- BMC Emergency Medicine
- volume
- 21
- issue
- 1
- article number
- 127
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:34717541
- scopus:85118237715
- ISSN
- 1471-227X
- DOI
- 10.1186/s12873-021-00519-y
- project
- MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021, The Author(s).
- id
- 5a92128b-6ce7-44ad-8929-4f35df6cdb47
- date added to LUP
- 2021-11-22 11:33:23
- date last changed
- 2024-06-01 20:16:14
@article{5a92128b-6ce7-44ad-8929-4f35df6cdb47, abstract = {{<p>Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was > 9 times higher in Q4. Conclusion: Glycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.</p>}}, author = {{Wiklund, Karolin and Gränsbo, Klas and Almgren, Peter and Peyman, Marjaneh and Tegnér, Lena and Toni-Bengtsson, Maria and Wieloch, Mattias and Melander, Olle}}, issn = {{1471-227X}}, keywords = {{Amino acids; Dyspnea; Emergency service, hospital; Glycine; Phenylalanine; Valine}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Emergency Medicine}}, title = {{Amino acids predict prognosis in patients with acute dyspnea}}, url = {{http://dx.doi.org/10.1186/s12873-021-00519-y}}, doi = {{10.1186/s12873-021-00519-y}}, volume = {{21}}, year = {{2021}}, }