C-Kit signal transduction and involvement in cancer
Lennartsson, Johan ; Voytyuk, Olexandr LU ; Heiss, Elke LU ; Sundberg, Christina LU ; Sun, Jianmin LU and Rönnstrand, Lars LU
(2005)
In Cancer Therapy
3.
p.5-28
- Abstract
- Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity
towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of
cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by... (More) - Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity
towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of
cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by which c-Kit induces signal transduction as well as describing tumors in
which c-Kit function is perturbed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/621260
- author
- Lennartsson, Johan
; Voytyuk, Olexandr
LU
; Heiss, Elke
LU
; Sundberg, Christina
LU
; Sun, Jianmin
LU
and Rönnstrand, Lars
LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fertility, Phospholipase C-g, PI3-kinase, Ras/Erk pathway, degradation, Transcription factors, Adapter proteins, tyrosine kinases, c-Kit signal transduction, Dimerization, Internalization, cancer, Protein tyrosine phosphatases, Hematopoiesis, Gastrointestinal tract, Nervous system, Mastocytosis, Melanoma, Small-cell lung cancer, JAK/STAT pathway, homeostasis, Pigmentation
- in
- Cancer Therapy
- volume
- 3
- pages
- 5 - 28
- publisher
- International Society of Cancer Therapy
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
- id
- db016dc3-601f-46a9-8eb9-e9cce6b9bd77 (old id 621260)
- alternative location
- http://www.cancer-therapy.org/volume3_2005/02_Lennartsson/02._Lennartsson,_5-28.pdf
- date added to LUP
- 2016-04-04 11:42:55
- date last changed
- 2019-05-22 02:18:15
@article{db016dc3-601f-46a9-8eb9-e9cce6b9bd77,
abstract = {{Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity<br/><br>
towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of<br/><br>
cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by which c-Kit induces signal transduction as well as describing tumors in<br/><br>
which c-Kit function is perturbed.}},
author = {{Lennartsson, Johan and Voytyuk, Olexandr and Heiss, Elke and Sundberg, Christina and Sun, Jianmin and Rönnstrand, Lars}},
keywords = {{Fertility; Phospholipase C-g; PI3-kinase; Ras/Erk pathway; degradation; Transcription factors; Adapter proteins; tyrosine kinases; c-Kit signal transduction; Dimerization; Internalization; cancer; Protein tyrosine phosphatases; Hematopoiesis; Gastrointestinal tract; Nervous system; Mastocytosis; Melanoma; Small-cell lung cancer; JAK/STAT pathway; homeostasis; Pigmentation}},
language = {{eng}},
pages = {{5--28}},
publisher = {{International Society of Cancer Therapy}},
series = {{Cancer Therapy}},
title = {{C-Kit signal transduction and involvement in cancer}},
url = {{http://www.cancer-therapy.org/volume3_2005/02_Lennartsson/02._Lennartsson,_5-28.pdf}},
volume = {{3}},
year = {{2005}},
}