Variable interatrial conduction illustrated in a hypertrophic cardiomyopathy population
(2007) In Annals of Noninvasive Electrocardiology 12(3). p.227-236- Abstract
- Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were... (More)
- Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed. The P-wave duration was longer in the HCM patients compared to the controls (149 +/- 22 vs 130 +/- 16 ms, P < 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z. Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/645995
- author
- Holmqvist, Fredrik LU ; Platonov, Pyotr LU ; Carlson, Jonas LU ; Havmöller, Rasmus LU ; Waktare, Johan E. P. ; McKenna, William J. ; Olsson, Bertil LU and Meurling, Carl LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ECG analysis, noninvasive, hypertrophic cardiomyopathy, atrial fibrillation, signal-averaged
- in
- Annals of Noninvasive Electrocardiology
- volume
- 12
- issue
- 3
- pages
- 227 - 236
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000247817000007
- scopus:34447119528
- pmid:17617068
- ISSN
- 1082-720X
- DOI
- 10.1111/j.1542-474X.2007.00166.x
- language
- English
- LU publication?
- yes
- id
- 5b0fd3b2-f193-4bdb-a3ee-fbde5bedd9bc (old id 645995)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17617068&dopt=Abstract
- date added to LUP
- 2016-04-01 11:35:18
- date last changed
- 2022-01-26 07:20:41
@article{5b0fd3b2-f193-4bdb-a3ee-fbde5bedd9bc, abstract = {{Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was compared with that of matched controls in order to explore the nature of the atrial conduction alterations. Methods and Results: A total of 65 patients (45 men, mean age 49 +/- 15) with HCM were included. The control population (n = 65) was age and gender matched (45 men, mean age 49 +/- 15). Five minutes of 12-lead ECG was recorded. The data were subsequently transformed to orthogonal lead data, and unfiltered signal-averaged P-wave analysis was performed. The P-wave duration was longer in the HCM patients compared to the controls (149 +/- 22 vs 130 +/- 16 ms, P < 0.0001). Examination of the P-wave morphology demonstrated changes in conduction patterns compatible with interatrial conduction block of varying severity in both groups, but a higher degree of interatrial block seen in the HCM population. These changes were most prominent in the Leads Y and Z. Conclusion: The present study suggests that the longer P-wave duration observed in HCM patients may be explained by a higher prevalence of block in one or more of the interatrial conduction routes.}}, author = {{Holmqvist, Fredrik and Platonov, Pyotr and Carlson, Jonas and Havmöller, Rasmus and Waktare, Johan E. P. and McKenna, William J. and Olsson, Bertil and Meurling, Carl}}, issn = {{1082-720X}}, keywords = {{ECG analysis; noninvasive; hypertrophic cardiomyopathy; atrial fibrillation; signal-averaged}}, language = {{eng}}, number = {{3}}, pages = {{227--236}}, publisher = {{Wiley-Blackwell}}, series = {{Annals of Noninvasive Electrocardiology}}, title = {{Variable interatrial conduction illustrated in a hypertrophic cardiomyopathy population}}, url = {{http://dx.doi.org/10.1111/j.1542-474X.2007.00166.x}}, doi = {{10.1111/j.1542-474X.2007.00166.x}}, volume = {{12}}, year = {{2007}}, }