Mitotic spindle as therapeutic target for tetraploid cancer cells
(2021) In Eurasian Journal of Medicine and Oncology 5(3). p.205-208- Abstract
Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentially the spindle pole apparatus and the spindle assembly checkpoint pathways.
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https://lup.lub.lu.se/record/65406203-3557-404c-9e87-9673cca57c18
- author
- Jemaà, Mohamed LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Centrosome apparatus, Mitotic catastrophe, Spindle assembly checkpoint, Tetraploidy
- in
- Eurasian Journal of Medicine and Oncology
- volume
- 5
- issue
- 3
- pages
- 4 pages
- publisher
- Kare Publishing
- external identifiers
-
- scopus:85117359475
- ISSN
- 2587-2400
- DOI
- 10.14744/ejmo.2021.13872
- language
- English
- LU publication?
- yes
- id
- 65406203-3557-404c-9e87-9673cca57c18
- date added to LUP
- 2022-03-09 16:49:21
- date last changed
- 2022-10-07 10:48:04
@article{65406203-3557-404c-9e87-9673cca57c18, abstract = {{<p>Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentially the spindle pole apparatus and the spindle assembly checkpoint pathways.</p>}}, author = {{Jemaà, Mohamed}}, issn = {{2587-2400}}, keywords = {{Centrosome apparatus; Mitotic catastrophe; Spindle assembly checkpoint; Tetraploidy}}, language = {{eng}}, number = {{3}}, pages = {{205--208}}, publisher = {{Kare Publishing}}, series = {{Eurasian Journal of Medicine and Oncology}}, title = {{Mitotic spindle as therapeutic target for tetraploid cancer cells}}, url = {{http://dx.doi.org/10.14744/ejmo.2021.13872}}, doi = {{10.14744/ejmo.2021.13872}}, volume = {{5}}, year = {{2021}}, }