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Mitotic spindle as therapeutic target for tetraploid cancer cells

Jemaà, Mohamed LU (2021) In Eurasian Journal of Medicine and Oncology 5(3). p.205-208
Abstract

Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentially the spindle pole apparatus and the spindle assembly checkpoint pathways.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Centrosome apparatus, Mitotic catastrophe, Spindle assembly checkpoint, Tetraploidy
in
Eurasian Journal of Medicine and Oncology
volume
5
issue
3
pages
4 pages
publisher
Kare Publishing
external identifiers
  • scopus:85117359475
ISSN
2587-2400
DOI
10.14744/ejmo.2021.13872
language
English
LU publication?
yes
id
65406203-3557-404c-9e87-9673cca57c18
date added to LUP
2022-03-09 16:49:21
date last changed
2022-10-07 10:48:04
@article{65406203-3557-404c-9e87-9673cca57c18,
  abstract     = {{<p>Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentially the spindle pole apparatus and the spindle assembly checkpoint pathways.</p>}},
  author       = {{Jemaà, Mohamed}},
  issn         = {{2587-2400}},
  keywords     = {{Centrosome apparatus; Mitotic catastrophe; Spindle assembly checkpoint; Tetraploidy}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{205--208}},
  publisher    = {{Kare Publishing}},
  series       = {{Eurasian Journal of Medicine and Oncology}},
  title        = {{Mitotic spindle as therapeutic target for tetraploid cancer cells}},
  url          = {{http://dx.doi.org/10.14744/ejmo.2021.13872}},
  doi          = {{10.14744/ejmo.2021.13872}},
  volume       = {{5}},
  year         = {{2021}},
}