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Cerebrospinal fluid protein reactions during non-neurological surgery

Anckarsater, R. ; Vasic, N. ; Jideus, L. ; Kristiansson, M. ; Zetterberg, H. ; Blennow, K. and Anckarsäter, Henrik LU (2007) In Acta Neurologica Scandinavica 115(4). p.254-259
Abstract
Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF... (More)
Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
spinal anaesthesia, stress, inflammation, fluid, cerebrospinal, blood-brain barrier, albumin, beta-2-microglobuline
in
Acta Neurologica Scandinavica
volume
115
issue
4
pages
254 - 259
publisher
Wiley-Blackwell
external identifiers
  • wos:000245054800006
  • scopus:33947391218
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2006.00741.x
language
English
LU publication?
yes
id
925e81bd-91eb-467e-8272-585cfc930526 (old id 669970)
date added to LUP
2016-04-01 16:27:09
date last changed
2022-02-05 08:21:22
@article{925e81bd-91eb-467e-8272-585cfc930526,
  abstract     = {{Objective- To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Methods- Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results- Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta 2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (beta TP) remained unchanged. Conclusins- Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.}},
  author       = {{Anckarsater, R. and Vasic, N. and Jideus, L. and Kristiansson, M. and Zetterberg, H. and Blennow, K. and Anckarsäter, Henrik}},
  issn         = {{1600-0404}},
  keywords     = {{spinal anaesthesia; stress; inflammation; fluid; cerebrospinal; blood-brain barrier; albumin; beta-2-microglobuline}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{254--259}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Neurologica Scandinavica}},
  title        = {{Cerebrospinal fluid protein reactions during non-neurological surgery}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0404.2006.00741.x}},
  doi          = {{10.1111/j.1600-0404.2006.00741.x}},
  volume       = {{115}},
  year         = {{2007}},
}