Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution
(2007) In Journal of Pharmaceutical Sciences 96(2). p.258-263- Abstract
- Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel... (More)
- Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel are dependent on their size and physicochemical properties. In addition, we show that mucin gel acts as an efficient selective barrier. It favors the disintegration of mixed micelles of nonionic and cationic surfactants by stopping the diffusion of cationic surfactants with slightly affecting the diffusion of the nonionic surfactants. (c) 2006 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/675135
- author
- Lafitte, Géraldine LU ; Thuresson, Krister LU and Söderman, Olle LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diffusion, glycoproteins, mucin gel, imaging methods, NMR, transport, drug
- in
- Journal of Pharmaceutical Sciences
- volume
- 96
- issue
- 2
- pages
- 258 - 263
- publisher
- Elsevier
- external identifiers
-
- wos:000243957600003
- scopus:33847656731
- ISSN
- 0022-3549
- DOI
- 10.1002/jps.20749
- language
- English
- LU publication?
- yes
- id
- d3110e3c-5675-4b3d-8dec-d71fd0b6de08 (old id 675135)
- date added to LUP
- 2016-04-01 11:57:16
- date last changed
- 2023-02-12 18:33:11
@article{d3110e3c-5675-4b3d-8dec-d71fd0b6de08, abstract = {{Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel are dependent on their size and physicochemical properties. In addition, we show that mucin gel acts as an efficient selective barrier. It favors the disintegration of mixed micelles of nonionic and cationic surfactants by stopping the diffusion of cationic surfactants with slightly affecting the diffusion of the nonionic surfactants. (c) 2006 Wiley-Liss, Inc.}}, author = {{Lafitte, Géraldine and Thuresson, Krister and Söderman, Olle}}, issn = {{0022-3549}}, keywords = {{diffusion; glycoproteins; mucin gel; imaging methods; NMR; transport; drug}}, language = {{eng}}, number = {{2}}, pages = {{258--263}}, publisher = {{Elsevier}}, series = {{Journal of Pharmaceutical Sciences}}, title = {{Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution}}, url = {{http://dx.doi.org/10.1002/jps.20749}}, doi = {{10.1002/jps.20749}}, volume = {{96}}, year = {{2007}}, }