TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial
(2006) In Annals of the New York Academy of Sciences 1079. p.320-326- Abstract
- The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and... (More)
- The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/679400
- author
- Hagopian, William A.
; Lernmark, Åke
LU
; Rewers, Marian J. ; Simell, Olli G. ; She, Jin-Xiong ; Ziegler, Anette G. ; Krischer, Jeffrey P. and Akolkar, Beena
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- type 1 diabetes, islet autoantibodies, HLA, virus
- in
- Annals of the New York Academy of Sciences
- volume
- 1079
- pages
- 320 - 326
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000243126100049
- scopus:33845701367
- ISSN
- 0077-8923
- DOI
- 10.1196/annals.1375.049
- language
- English
- LU publication?
- yes
- id
- 617d1496-515e-4ba9-92c5-b877c990af9d (old id 679400)
- date added to LUP
- 2016-04-01 15:47:04
- date last changed
- 2022-03-30 03:03:07
@article{617d1496-515e-4ba9-92c5-b877c990af9d, abstract = {{The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.}}, author = {{Hagopian, William A. and Lernmark, Åke and Rewers, Marian J. and Simell, Olli G. and She, Jin-Xiong and Ziegler, Anette G. and Krischer, Jeffrey P. and Akolkar, Beena}}, issn = {{0077-8923}}, keywords = {{type 1 diabetes; islet autoantibodies; HLA; virus}}, language = {{eng}}, pages = {{320--326}}, publisher = {{Wiley-Blackwell}}, series = {{Annals of the New York Academy of Sciences}}, title = {{TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial}}, url = {{http://dx.doi.org/10.1196/annals.1375.049}}, doi = {{10.1196/annals.1375.049}}, volume = {{1079}}, year = {{2006}}, }