Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Pagani, Alberto ; Pollastro, Federica ; Spera, Silvia ; Ballero, Mauro ; Sterner, Olov LU and Appendino, Giovanni (2007) In Natural Product Communications 2(6). p.637-642
Abstract
A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SERCA, Thapsia garganica, neohelmanthicin D, thapsivillosin J, thapsigargin, thapsigargicin
in
Natural Product Communications
volume
2
issue
6
pages
637 - 642
publisher
Natural Products Inc
external identifiers
  • wos:000249007800004
  • scopus:78549265885
ISSN
1934-578X
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
37274592-efd5-4e5a-a5cc-5ac46e2817a2 (old id 688887)
date added to LUP
2016-04-01 11:55:08
date last changed
2022-01-26 20:10:35
@article{37274592-efd5-4e5a-a5cc-5ac46e2817a2,
  abstract     = {{A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.}},
  author       = {{Pagani, Alberto and Pollastro, Federica and Spera, Silvia and Ballero, Mauro and Sterner, Olov and Appendino, Giovanni}},
  issn         = {{1934-578X}},
  keywords     = {{SERCA; Thapsia garganica; neohelmanthicin D; thapsivillosin J; thapsigargin; thapsigargicin}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{637--642}},
  publisher    = {{Natural Products Inc}},
  series       = {{Natural Product Communications}},
  title        = {{An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin}},
  volume       = {{2}},
  year         = {{2007}},
}