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Idac-alpha : An alpha dosimetry software for normal organs and tissues

Andersson, M. LU ; Kluge, A. ; Meyer, T. ; Koumarianou, E. and Mattsson, S. LU (2021) In Radiation Protection Dosimetry 195(3-4). p.327-333
Abstract

Radiopharmaceuticals have been used for the treatment of various forms of cancer since the 1940s. In recent years, the advantages of alpha emitting radionuclides have emerged as a favourable treatment option. However, most alpha emitting radionuclides have long decay chains with long-lived daughter radionuclides. This leads to uncertainties in the dosimetry for normal organs and tissues, when established dosimetry models are employed. The aim of this project is to assign each progeny its own biokinetic behaviour. The novel dosimetry model was applied to 223Ra-dichloride, frequently used for the treatment of patients with metastatic bone disease from castration-resistant prostate cancer. In this dosimetry model, individual biokinetics... (More)

Radiopharmaceuticals have been used for the treatment of various forms of cancer since the 1940s. In recent years, the advantages of alpha emitting radionuclides have emerged as a favourable treatment option. However, most alpha emitting radionuclides have long decay chains with long-lived daughter radionuclides. This leads to uncertainties in the dosimetry for normal organs and tissues, when established dosimetry models are employed. The aim of this project is to assign each progeny its own biokinetic behaviour. The novel dosimetry model was applied to 223Ra-dichloride, frequently used for the treatment of patients with metastatic bone disease from castration-resistant prostate cancer. In this dosimetry model, individual biokinetics for each daughter radionuclide was included. This resulted in a decrease in absorbed dose to bone surfaces and red marrow and increased absorbed dose to liver and kidney, when compared with dosimetry models assuming that the daughter nuclides follow the biokinetics of the parent radionuclide.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
195
issue
3-4
pages
7 pages
publisher
Oxford University Press
external identifiers
  • scopus:85114338506
  • pmid:33839784
ISSN
0144-8420
DOI
10.1093/rpd/ncab046
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press. All rights reserved.
id
6922a03d-a766-497c-842a-a1f684ac9415
date added to LUP
2022-02-25 12:00:46
date last changed
2024-08-12 14:17:18
@article{6922a03d-a766-497c-842a-a1f684ac9415,
  abstract     = {{<p>Radiopharmaceuticals have been used for the treatment of various forms of cancer since the 1940s. In recent years, the advantages of alpha emitting radionuclides have emerged as a favourable treatment option. However, most alpha emitting radionuclides have long decay chains with long-lived daughter radionuclides. This leads to uncertainties in the dosimetry for normal organs and tissues, when established dosimetry models are employed. The aim of this project is to assign each progeny its own biokinetic behaviour. The novel dosimetry model was applied to 223Ra-dichloride, frequently used for the treatment of patients with metastatic bone disease from castration-resistant prostate cancer. In this dosimetry model, individual biokinetics for each daughter radionuclide was included. This resulted in a decrease in absorbed dose to bone surfaces and red marrow and increased absorbed dose to liver and kidney, when compared with dosimetry models assuming that the daughter nuclides follow the biokinetics of the parent radionuclide. </p>}},
  author       = {{Andersson, M. and Kluge, A. and Meyer, T. and Koumarianou, E. and Mattsson, S.}},
  issn         = {{0144-8420}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{3-4}},
  pages        = {{327--333}},
  publisher    = {{Oxford University Press}},
  series       = {{Radiation Protection Dosimetry}},
  title        = {{Idac-alpha : An alpha dosimetry software for normal organs and tissues}},
  url          = {{http://dx.doi.org/10.1093/rpd/ncab046}},
  doi          = {{10.1093/rpd/ncab046}},
  volume       = {{195}},
  year         = {{2021}},
}