Variation in human milk composition is related to differences in milk and infant fecal microbial communities
(2021) In Microorganisms 9(6).- Abstract
Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into... (More)
Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.
(Less)
- author
- organization
- publishing date
- 2021-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bacteria, Breastmilk, Gastrointestinal tract, HMO, Human milk, Infant, Lactose, Microbiome, Oligosaccharides, Protein
- in
- Microorganisms
- volume
- 9
- issue
- 6
- article number
- 1153
- publisher
- MDPI AG
- external identifiers
-
- pmid:34072117
- scopus:85106585862
- ISSN
- 2076-2607
- DOI
- 10.3390/microorganisms9061153
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: Funding: This research was funded by the National Science Foundation IOS-BIO 1344288; the Ministry of Economy and Competitiveness, Spain (AGL2013-4190-P); the European Commission (624773-FP-7-PEOPLE-2013-IEF, to LR); and in part by National Institutes of Health NICHD R01-HD092297 and COBRE Phase III grant P30GM103324. Sterile, single-use milk collection kits were provided by Medela Inc.
- id
- 69e79b28-7058-45c9-9d8c-300c26308723
- date added to LUP
- 2021-06-10 14:34:18
- date last changed
- 2024-07-13 14:46:16
@article{69e79b28-7058-45c9-9d8c-300c26308723,
abstract = {{<p>Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.</p>}},
author = {{Pace, Ryan M. and Williams, Janet E. and Robertson, Bianca and Lackey, Kimberly A. and Meehan, Courtney L. and Price, William J. and Foster, James A. and Sellen, Daniel W. and Kamau-Mbuthia, Elizabeth W. and Kamundia, Egidioh W. and Mbugua, Samwel and Moore, Sophie E. and Prentice, Andrew M. and Kita, Debela G. and Kvist, Linda J. and Otoo, Gloria E. and Ruiz, Lorena and Rodríguez, Juan M. and Pareja, Rossina G. and McGuire, Mark A. and Bode, Lars and McGuire, Michelle K.}},
issn = {{2076-2607}},
keywords = {{Bacteria; Breastmilk; Gastrointestinal tract; HMO; Human milk; Infant; Lactose; Microbiome; Oligosaccharides; Protein}},
language = {{eng}},
month = {{06}},
number = {{6}},
publisher = {{MDPI AG}},
series = {{Microorganisms}},
title = {{Variation in human milk composition is related to differences in milk and infant fecal microbial communities}},
url = {{http://dx.doi.org/10.3390/microorganisms9061153}},
doi = {{10.3390/microorganisms9061153}},
volume = {{9}},
year = {{2021}},
}